The Consult by the Association of Physicians Sat, 25 Jul 2026 04:16:23 +0100 en © 2026 The Consult by the Association of Physicians yes f0c745cf-c3d1-5087-9241-70d3060ae699 Association of Physicians of Great Britain & Ireland episodic false  The Consult is a dedicated podcast for clinicians, researchers and healthcare professionals who want to stay close to the latest developments in clinical science and medicine. Hosted by Professor Paul Klenerman, the series brings together multidisciplinary experts to explore emerging research, new evidence and the discoveries shaping clinical practice as they unfold. Subscribe for authoritative conversations, timely insights and a clearer understanding of the science transforming patient care. 

]]> Buzzsprout (https://www.buzzsprout.com) Association of Physicians of Great Britain & Ireland https://storage.buzzsprout.com/3oxp5nq7j5w6u9p0u5s94qdmuyuq?.jpg The Consult by the Association of Physicians THE CONSULT: A precision medicine approach to colorectal cancer prevention using the omega (n)-3 polyunsaturated fatty acid (PUFA) EPA THE CONSULT: A precision medicine approach to colorectal cancer prevention using the omega (n)-3 polyunsaturated fatty acid (PUFA) EPA These recent papers describe work in the field of stromal cell biology. Fibroblasts were long regarded as simple structural cells and often ignored by immunologists. In these studies of human disease Chris Buckley discusses how recent approaches based on transcriptomics have shone new light on these cells and their role in disease. Given their long lived nature and capacity to remain resident in tissues, they may play particular roles in chronic inflammation. New data allows subsets of such cells to be delineated and potentially in future targeted to provide new therapies in inflammatory disease. Importantly, Prof. Buckley talks here (and in a recent webinar hosted by the Association of Physicians) about how innovative approaches to inflammatory disease can allow targeting of multiple different diseases, based on a deep understanding of the underlying pathology.


Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin.

Clark KE, Xu S, Attar M, Ong VH, Buckley CD, Denton CP.JCI Insight. 2025 Apr 15;10(10):e185618. doi: 10.1172/jci.insight.185618. eCollection 2025 May 22.PMID: 40232859 Free PMC article.

Molecular and spatial analysis of tertiary lymphoid structures in Sjogren's syndrome.

Nayar S, Turner JD, Asam S, Fennell E, Pugh M, Colafrancesco S, Berardicurti O, Smith CG, Flint J, Teodosio A, Iannizzotto V, Gardner DH, van Roon J, Korsunsky I, Howdle D; Roche Fibroblast Network Consortium; Frei AP, Lassen KG, Bowman SJ, Ng WF, Croft AP, Filer A, Fisher BA, Buckley CD, Barone F.Nat Commun. 2025 Jan 2;16(1):5. doi: 10.1038/s41467-024-54686-0.PMID: 39747819 Free PMC article.

Wnt signaling drives stromal inflammation in inflammatory arthritis.

Mueller AA, Zou AE, Marsh LJ, Kemble S, Nayar S, Watts GFM, Murphy CL, Taylor E, Major T, Gardner D, Buckley CD, Wei K, Raychaudhuri S, Korsunsky I, Filer A, Croft AP, Brenner MB.bioRxiv [Preprint]. 2025 Jan 8:2025.01.06.631510. doi: 10.1101/2025.01.06.631510.PMID: 39829745 Free PMC article. Preprint.

]]> These recent papers describe work in the field of stromal cell biology. Fibroblasts were long regarded as simple structural cells and often ignored by immunologists. In these studies of human disease Chris Buckley discusses how recent approaches based on transcriptomics have shone new light on these cells and their role in disease. Given their long lived nature and capacity to remain resident in tissues, they may play particular roles in chronic inflammation. New data allows subsets of such cells to be delineated and potentially in future targeted to provide new therapies in inflammatory disease. Importantly, Prof. Buckley talks here (and in a recent webinar hosted by the Association of Physicians) about how innovative approaches to inflammatory disease can allow targeting of multiple different diseases, based on a deep understanding of the underlying pathology.


Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin.

Clark KE, Xu S, Attar M, Ong VH, Buckley CD, Denton CP.JCI Insight. 2025 Apr 15;10(10):e185618. doi: 10.1172/jci.insight.185618. eCollection 2025 May 22.PMID: 40232859 Free PMC article.

Molecular and spatial analysis of tertiary lymphoid structures in Sjogren's syndrome.

Nayar S, Turner JD, Asam S, Fennell E, Pugh M, Colafrancesco S, Berardicurti O, Smith CG, Flint J, Teodosio A, Iannizzotto V, Gardner DH, van Roon J, Korsunsky I, Howdle D; Roche Fibroblast Network Consortium; Frei AP, Lassen KG, Bowman SJ, Ng WF, Croft AP, Filer A, Fisher BA, Buckley CD, Barone F.Nat Commun. 2025 Jan 2;16(1):5. doi: 10.1038/s41467-024-54686-0.PMID: 39747819 Free PMC article.

Wnt signaling drives stromal inflammation in inflammatory arthritis.

Mueller AA, Zou AE, Marsh LJ, Kemble S, Nayar S, Watts GFM, Murphy CL, Taylor E, Major T, Gardner D, Buckley CD, Wei K, Raychaudhuri S, Korsunsky I, Filer A, Croft AP, Brenner MB.bioRxiv [Preprint]. 2025 Jan 8:2025.01.06.631510. doi: 10.1101/2025.01.06.631510.PMID: 39829745 Free PMC article. Preprint.

]]> Association of Physicians Buzzsprout-19546551 Sat, 25 Jul 2026 04:00:00 +0100 2830 full false THE CONSULT: Professor Paul Klenerman talks with Professor Christopher Buckley about his recent papers. THE CONSULT: Professor Paul Klenerman talks with Professor Christopher Buckley about his recent papers. Professor Paul Klenerman talks with Professor Christopher Buckley about his recent papers.

Professor Paul Klenerman

Sidney Truelove Professorship of Gastroenterology, Nuffield Department of Medicine; Fellow of Green Templeton College, University of Oxford

Professor Christopher Buckley

Director of Clinical Research, Kennedy Institute of Rheumatology, University of Oxford

The opinions of our host and guests are their own; AoP does not endorse any individual viewpoints, given products or companies.

]]> Professor Paul Klenerman talks with Professor Christopher Buckley about his recent papers.

Professor Paul Klenerman

Sidney Truelove Professorship of Gastroenterology, Nuffield Department of Medicine; Fellow of Green Templeton College, University of Oxford

Professor Christopher Buckley

Director of Clinical Research, Kennedy Institute of Rheumatology, University of Oxford

The opinions of our host and guests are their own; AoP does not endorse any individual viewpoints, given products or companies.

]]> Association of Physicians Buzzsprout-19546527 Sat, 25 Jul 2026 03:00:00 +0100 1473 full false