One in Six Billion Thu, 12 Mar 2026 05:05:08 -0400 https://www.buzzsprout.com/2266317 en-gb © 2026 One in Six Billion yes 46bba101-15b0-590c-8c8a-da992eea0d25 Andrew Hattersley and Maggie Shepherd episodic false A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.

]]> Buzzsprout (https://www.buzzsprout.com) Andrew Hattersley and Maggie Shepherd https://storage.buzzsprout.com/ol57e5x5b0ux225wi9klkvh3y4aj?.jpg One in Six Billion Special Episode 8: Steve Chapman, Andrew Hattersley and Maggie Shepherd. Final reflections on making the One in Six billion podcast. Special Episode 8: Steve Chapman, Andrew Hattersley and Maggie Shepherd. Final reflections on making the One in Six billion podcast. In the final episode of the One in Six Billion podcast Andrew and Maggie reflect with producer Steve Chapman on the fun they have had making 51 podcasts with 70 guests in the past 2 years.

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]]> In the final episode of the One in Six Billion podcast Andrew and Maggie reflect with producer Steve Chapman on the fun they have had making 51 podcasts with 70 guests in the past 2 years.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-18080496 Tue, 28 Oct 2025 09:00:00 +0000 1529 1in6b:S.8, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Steve Chapman 4 bonus false Series 4 Episode 8. Rohini Bajekal and Shivani Misra. The challenge of diagnosing monogenic diabetes in South Asians Series 4 Episode 8. Rohini Bajekal and Shivani Misra. The challenge of diagnosing monogenic diabetes in South Asians Rohini Bajekal describes how she had years of receiving inappropriate lifestyle advice before Glucokinase MODY was diagnosed.  Dr Shivani Misra’s research has shown that failure to diagnose monogenic diabetes is even common in South Asians than in the white European population.

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]]> Rohini Bajekal describes how she had years of receiving inappropriate lifestyle advice before Glucokinase MODY was diagnosed.  Dr Shivani Misra’s research has shown that failure to diagnose monogenic diabetes is even common in South Asians than in the white European population.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17625029 Tue, 14 Oct 2025 09:00:00 +0100 2147 1in6b:4.8, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Rohini Bajekal, Shivani 4 8 full false Series 4 episode 7. Sarah Richardson. Small extra-islet beta cells matter Series 4 episode 7. Sarah Richardson. Small extra-islet beta cells matter Sarah Richardson talks about her new exciting research on insulin producing beta-cells that are single cells or small clusters rather than in islets.  These extra-islet beta-cells make up most of the insulin producing capacity of the pancreas in young children and are particularly susceptible to immune attack in Type 1 diabetes.  This important research explains why the loss of insulin producing cells in Type 1 diabetes is more severe in young children and informs future work on treating and preventing Type 1 diabetes.

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]]> Sarah Richardson talks about her new exciting research on insulin producing beta-cells that are single cells or small clusters rather than in islets.  These extra-islet beta-cells make up most of the insulin producing capacity of the pancreas in young children and are particularly susceptible to immune attack in Type 1 diabetes.  This important research explains why the loss of insulin producing cells in Type 1 diabetes is more severe in young children and informs future work on treating and preventing Type 1 diabetes.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17903899 Tue, 30 Sep 2025 09:00:00 +0100 1287 1in6b:4.7, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Sarah Richardson 4 7 full false Series 4 episode 6: Hannah Robinson and Nick Thomas. Taking immunotherapy to delay adult-onset Type 1 diabetes Series 4 episode 6: Hannah Robinson and Nick Thomas. Taking immunotherapy to delay adult-onset Type 1 diabetes Hannah Robinson was the first adult in the UK to be given the new immunotherapy drug Teplizumab, which aims to slow down the development of type 1 diabetes. Hannah had multiple pancreatic autoantibodies and hence is on the path to developing Type 1 diabetes (Series 4 Episode 3). Her consultant, Nick Thomas, arranged 14 consecutive daily hospital visits for her to receive the drug through a drip. 

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]]> Hannah Robinson was the first adult in the UK to be given the new immunotherapy drug Teplizumab, which aims to slow down the development of type 1 diabetes. Hannah had multiple pancreatic autoantibodies and hence is on the path to developing Type 1 diabetes (Series 4 Episode 3). Her consultant, Nick Thomas, arranged 14 consecutive daily hospital visits for her to receive the drug through a drip. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17840746 Tue, 16 Sep 2025 09:00:00 +0100 1135 1in6b:4.6, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Hannah Robinson, Nick Thomas 4 6 full false Series 4 episode 5. Jerry Gore and Rob Andrews. Living life on the edge with Type 1 diabetes. Series 4 episode 5. Jerry Gore and Rob Andrews. Living life on the edge with Type 1 diabetes. Jerry Gore has always lived life on the edge; he had tackled some of the highest, and most inhospitable mountain climbs in the world before he was diagnosed with Type 1 diabetes aged 40.  His Type 1 diabetes has not held him back and he has learnt how to live well with his Type 1 diabetes when climbing at extreme altitude and bitter cold.  He helps people living with Type 1 diabetes throughout the world, especially in S E Asia as co-founder of Action4Diabetes (A4D). Rob Andrews is a national expert helping people with Type 1 diabetes to adapt their diabetes care so they can do any extreme activity including mountaineering, long distance swimming, and endurance cycling.

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]]> Jerry Gore has always lived life on the edge; he had tackled some of the highest, and most inhospitable mountain climbs in the world before he was diagnosed with Type 1 diabetes aged 40.  His Type 1 diabetes has not held him back and he has learnt how to live well with his Type 1 diabetes when climbing at extreme altitude and bitter cold.  He helps people living with Type 1 diabetes throughout the world, especially in S E Asia as co-founder of Action4Diabetes (A4D). Rob Andrews is a national expert helping people with Type 1 diabetes to adapt their diabetes care so they can do any extreme activity including mountaineering, long distance swimming, and endurance cycling.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17754640 Tue, 02 Sep 2025 09:00:00 +0100 2082 1in6b:4.5, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Jerry Gore, Rob Andrews 4 5 full false Series 4 episode 4. Chris Bright and Rob Andrews. Type 1 diabetes and Elite Sport. Series 4 episode 4. Chris Bright and Rob Andrews. Type 1 diabetes and Elite Sport. Chris Bright was diagnosed with Type 1 diabetes aged 8 but this did not stop him having a very successful football career including playing international futsal for Wales. He describes the challenges he faced and how he over came them.  He has established The Diabetes Football Community that supports football for everyone living with Type 1 diabetes. Dr Rob Andrews helps people with Type 1 diabetes compete in all sports at the highest level.  He has set up the Exercise for Type 1 Diabetes (EXTOD) education program for patients and healthcare professionals.

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]]> Chris Bright was diagnosed with Type 1 diabetes aged 8 but this did not stop him having a very successful football career including playing international futsal for Wales. He describes the challenges he faced and how he over came them.  He has established The Diabetes Football Community that supports football for everyone living with Type 1 diabetes. Dr Rob Andrews helps people with Type 1 diabetes compete in all sports at the highest level.  He has set up the Exercise for Type 1 Diabetes (EXTOD) education program for patients and healthcare professionals.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17682927 Tue, 19 Aug 2025 09:00:00 +0100 2206 1in6b:4.4, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Chris Bright, Rob Andrews, elite sport 4 4 full false Series 4 episode 3: Hannah Robinson and Nick Thomas Series 4 episode 3: Hannah Robinson and Nick Thomas First steps in delaying adult-onset Type 1 diabetes

When Hannah Robinson was diagnosed with gestational diabetes and found to have islet auto-antibodies she was recognised as being on the path to future Type 1 diabetes.  With help from her diabetes consultant, Dr Nick Thomas, she became the first adult in the UK to be given Teplizumab, a new treatment that delays the onset of Type 1 diabetes.

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]]> First steps in delaying adult-onset Type 1 diabetes

When Hannah Robinson was diagnosed with gestational diabetes and found to have islet auto-antibodies she was recognised as being on the path to future Type 1 diabetes.  With help from her diabetes consultant, Dr Nick Thomas, she became the first adult in the UK to be given Teplizumab, a new treatment that delays the onset of Type 1 diabetes.

Send a text

]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17612306 Tue, 05 Aug 2025 09:00:00 +0100 1548 1in6b:4.3, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Hannah, Nick Thomas 4 3 full false Series 4 Episode 2. Rachel Besser. Identifying children before they develop Type 1 diabetes Series 4 Episode 2. Rachel Besser. Identifying children before they develop Type 1 diabetes Dr Rachel Besser explains how new treatment options means it is now important to identify children before they get symptomatic Type 1 diabetes.  Rachel is working to make sure testing for risk of Type 1 diabetes is done in the best way for children and their families.

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]]> Dr Rachel Besser explains how new treatment options means it is now important to identify children before they get symptomatic Type 1 diabetes.  Rachel is working to make sure testing for risk of Type 1 diabetes is done in the best way for children and their families.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17517988 Tue, 22 Jul 2025 09:00:00 +0100 1464 1in6b:4.2, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Grace Bervoets, Amanda Stride 4 2 full false Series 4 Episode 1. Richard Oram. First steps towards preventing Type 1 diabetes Series 4 Episode 1. Richard Oram. First steps towards preventing Type 1 diabetes Richard Oram explains how recent advances have meant we can now delay type 1 diabetes with immunotherapy.  To do this we need to be able to identify people at very high risk of developing Type 1 diabetes.  Richard thinks genetic analysis could play a part in this identification.

 

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]]> Richard Oram explains how recent advances have meant we can now delay type 1 diabetes with immunotherapy.  To do this we need to be able to identify people at very high risk of developing Type 1 diabetes.  Richard thinks genetic analysis could play a part in this identification.

 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17423844 Tue, 08 Jul 2025 09:00:00 +0100 1468 1in6b:3.18, diabetes, genetics, genes, andrew hattersley, Richard Oram, 1in6b:4.1 4 1 full false Series 3 Episode 17. Jennifer and Helen. Prader Willi syndrome: hunger that never goes away Series 3 Episode 17. Jennifer and Helen. Prader Willi syndrome: hunger that never goes away Jennifer and her mother Helen explain how being born Prader Willi syndrome has had a lifelong impact.  One challenge is that Jennifer is continually hungry, and so limiting access to food is needed at all times. 

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]]> Jennifer and her mother Helen explain how being born Prader Willi syndrome has had a lifelong impact.  One challenge is that Jennifer is continually hungry, and so limiting access to food is needed at all times. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17358220 Tue, 24 Jun 2025 09:00:00 +0100 2002 1in6b:3.17, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Jennifer, Helen, Prader Willi syndrome 3 17 full false Special episode 7. Maggie Shepherd (part 2). Inspirational nurse researcher and educator Special episode 7. Maggie Shepherd (part 2). Inspirational nurse researcher and educator Professor Maggie Shepherd reflects back on her career and how she made the massive steps from being a clinical nurse to becoming a nationally leading researcher and educator.

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]]> Professor Maggie Shepherd reflects back on her career and how she made the massive steps from being a clinical nurse to becoming a nationally leading researcher and educator.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17272367 Tue, 10 Jun 2025 09:00:00 +0100 1739 1in6b:special7, andrew hattersley, maggie shephard, diabetes, genes 3 bonus false Special episode 6. Andrew Hattersley (part 2). Building the Exeter diabetes research team Special episode 6. Andrew Hattersley (part 2). Building the Exeter diabetes research team Andrew Hattersley describes how teamwork and mutual support has helped the Exeter diabetes research team expand and flourish over the past 30 years

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]]> Andrew Hattersley describes how teamwork and mutual support has helped the Exeter diabetes research team expand and flourish over the past 30 years

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-17137893 Tue, 27 May 2025 09:00:00 +0100 1794 1in6b:special6, diabetes, genetics, genes, andrew hattersley, maggie shepherd 3 bonus false Series 3 Episode 16. Grace Bervoets and Amanda Stride. Cystic Fibrosis related Diabetes Series 3 Episode 16. Grace Bervoets and Amanda Stride. Cystic Fibrosis related Diabetes Grace Bervoets talks about living with cystic fibrosis and cystic fibrosis related-diabetes.  Amanada Stride, who works as a diabetes consultant helping people with cystic fibrosis related-diabetes, explains the many challenges of this unusual type of diabetes.

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]]> Grace Bervoets talks about living with cystic fibrosis and cystic fibrosis related-diabetes.  Amanada Stride, who works as a diabetes consultant helping people with cystic fibrosis related-diabetes, explains the many challenges of this unusual type of diabetes.

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]]> Buzzsprout-17102394 Tue, 13 May 2025 09:00:00 +0100 1944 1in6b:3.16, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Grace Bervoets, Amanda Stride 3 16 full false Series 3 Episode 15. Tom Staniford. MDP syndrome Series 3 Episode 15. Tom Staniford. MDP syndrome Tom Staniford talks about living with the MDP syndrome, an extremely rare genetic condition. MDP syndrome includes Mandibula hypoplasia, Deafness, and Progeroid features amongst its widespread features. Tom developed Type 2 diabetes as a teenager because of a loss of fat under the skin (lipodystrophy) despite being very thin and active.  Tom has used his communication and media skills to help other people with MDP syndrome get diagnosed and receive the right care.

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]]> Tom Staniford talks about living with the MDP syndrome, an extremely rare genetic condition. MDP syndrome includes Mandibula hypoplasia, Deafness, and Progeroid features amongst its widespread features. Tom developed Type 2 diabetes as a teenager because of a loss of fat under the skin (lipodystrophy) despite being very thin and active.  Tom has used his communication and media skills to help other people with MDP syndrome get diagnosed and receive the right care.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16981132 Tue, 29 Apr 2025 09:00:00 +0100 2578 1in6b:3.15, diabetes, genetics, genes, andrew hattersley, maggie shepherd, tom Staniford 3 15 full false Series 3 Episode 14: Farah O'Regan and Matt Johnson. Down syndrome and very young onset diabetes Series 3 Episode 14: Farah O'Regan and Matt Johnson. Down syndrome and very young onset diabetes Farah O'Regan talks about how her son who had Down syndrome and a severe congenital heart condition needing surgery diagnosed in pregnancy and then developed Type 1 diabetes on day 2 of life.  In early childhood he was diagnosed with 2 more autoimmune conditions, coeliac disease and hypothyroidism.  Researcher Matt Johnson explains his research which has established that Down syndrome directly results in very early-onset autoimmune diabetes. 

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]]> Farah O'Regan talks about how her son who had Down syndrome and a severe congenital heart condition needing surgery diagnosed in pregnancy and then developed Type 1 diabetes on day 2 of life.  In early childhood he was diagnosed with 2 more autoimmune conditions, coeliac disease and hypothyroidism.  Researcher Matt Johnson explains his research which has established that Down syndrome directly results in very early-onset autoimmune diabetes. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16951099 Tue, 15 Apr 2025 09:00:00 +0100 2006 1in6b:3.13, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Farah O'Regan, Matt Johnson 3 13 full false Series 3 Episode 13. Abby Gardener and Tim Barrett. Wolfram syndrome / WFS1 Spectrum disorder Series 3 Episode 13. Abby Gardener and Tim Barrett. Wolfram syndrome / WFS1 Spectrum disorder Abby Gardener describes how she was diagnosed with Wolfram syndrome after developing both insulin-treated diabetes and diabetes insipidus (when the urine cannot concentrate) and how this has impacted her life.  Professor Tim Barrett talks about how, throughout his career, he has been researching and providing care for patients with Wolfram syndrome.  

He explains that it is now recognised that there are a range of features that can result from the genetic change (WFS1 spectrum disorder) and that not every patient will have all the severe changes previously described in Wolframs syndrome.

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]]> Abby Gardener describes how she was diagnosed with Wolfram syndrome after developing both insulin-treated diabetes and diabetes insipidus (when the urine cannot concentrate) and how this has impacted her life.  Professor Tim Barrett talks about how, throughout his career, he has been researching and providing care for patients with Wolfram syndrome.  

He explains that it is now recognised that there are a range of features that can result from the genetic change (WFS1 spectrum disorder) and that not every patient will have all the severe changes previously described in Wolframs syndrome.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16863882 Tue, 01 Apr 2025 09:00:00 +0100 2093 1in6b:3.12, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Abby Gardener, Tim Barrett 3 13 full false Series 3 Episode 12. Cassi Connelly. Familial Partial Lipodystrophy Series 3 Episode 12. Cassi Connelly. Familial Partial Lipodystrophy Cassi Connelly talks about her experience of having familial partial lipodystrophy characterised by a loss of fat and muscular appearance of her arms and legs. She had multiple medical problems including diabetes for decades before the diagnosis of familial partial lipodystrophy was finally confirmed by a genetic test. Her treatment is now better tailored to her needs.

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]]> Cassi Connelly talks about her experience of having familial partial lipodystrophy characterised by a loss of fat and muscular appearance of her arms and legs. She had multiple medical problems including diabetes for decades before the diagnosis of familial partial lipodystrophy was finally confirmed by a genetic test. Her treatment is now better tailored to her needs.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16800948 Tue, 18 Mar 2025 09:00:00 +0000 2161 1in6b:12.3, 1in6b:3.12, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Cassi 3 12 full false Series 3 Episode 11. Rebecca Goodman. Living well with Bardet-Biedl syndrome. Series 3 Episode 11. Rebecca Goodman. Living well with Bardet-Biedl syndrome. Rebecca Goodman talks to Andrew and Maggie about what it is like to grow up with Bardet-Biedl syndrome. Features of Bardet-Biedl syndrome include extra fingers and toes, progressive blindness, kidney problems, obesity due to an uncontrolled appetite, insulin resistance and diabetes. Despite this long list of medical issues Rebecca lives independently and enjoys a full and fun life. 

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]]> Rebecca Goodman talks to Andrew and Maggie about what it is like to grow up with Bardet-Biedl syndrome. Features of Bardet-Biedl syndrome include extra fingers and toes, progressive blindness, kidney problems, obesity due to an uncontrolled appetite, insulin resistance and diabetes. Despite this long list of medical issues Rebecca lives independently and enjoys a full and fun life. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16717102 Tue, 04 Mar 2025 09:00:00 +0000 1754 1in6b:3.11, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Becky Goodman 3 11 full false Special episode 5. John Dennis. Research breakthrough in Type 2 diabetes treatment. Special episode 5. John Dennis. Research breakthrough in Type 2 diabetes treatment. We talk to John Dennis, a data science researcher working in the University of Exeter. He used data from 1 million people with Type 2 diabetes to discover how the clinical characteristics of a patient alter the glucose lowering with different treatments. John’s 5 drug model, published in the Lancet in late February 2025, uses simple clinical information to identify, for the first time, the best glucose lowering treatment for a patient.  The model selected best treatment lowers the glucose most, doubles  the time before another medication is needed and reduces long term complications of diabetes. See www.1in6b.com for more details. 

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]]> We talk to John Dennis, a data science researcher working in the University of Exeter. He used data from 1 million people with Type 2 diabetes to discover how the clinical characteristics of a patient alter the glucose lowering with different treatments. John’s 5 drug model, published in the Lancet in late February 2025, uses simple clinical information to identify, for the first time, the best glucose lowering treatment for a patient.  The model selected best treatment lowers the glucose most, doubles  the time before another medication is needed and reduces long term complications of diabetes. See www.1in6b.com for more details. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16525442 Tue, 18 Feb 2025 09:00:00 +0000 1441 1in6b:special5, diabetes, genetics, genes, andrew hattersley, maggie shepherd, John Dennis 3 bonus false Series 3 Episode 10. Julie Reynolds and Kash Patel. Maternally inherited diabetes and deafness Series 3 Episode 10. Julie Reynolds and Kash Patel. Maternally inherited diabetes and deafness Julie Reynolds describes how she gradually lost her hearing in her 30’s and developed diabetes in her 40’s these 2 conditions also developed in in her mother, her children and other maternal relative. This led to a diagnosis of maternally inherited diabetes and deafness that results from a change in the mitochondrial DNA.  Kash Patel explains the science between diabetes, deafness and a maternal inheritance and why there is a lot of variation in the presence and severity of clinical features

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]]> Julie Reynolds describes how she gradually lost her hearing in her 30’s and developed diabetes in her 40’s these 2 conditions also developed in in her mother, her children and other maternal relative. This led to a diagnosis of maternally inherited diabetes and deafness that results from a change in the mitochondrial DNA.  Kash Patel explains the science between diabetes, deafness and a maternal inheritance and why there is a lot of variation in the presence and severity of clinical features

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16525391 Tue, 04 Feb 2025 09:00:00 +0000 1985 1in6b:3.10, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Julie Reynolds, Kash Patel 3 10 full false Series 3 Episode 9. Ru Kovvuri and Rhian Clissold Cognitive and medical impacts of the HNF1B deletion syndrome Series 3 Episode 9. Ru Kovvuri and Rhian Clissold Cognitive and medical impacts of the HNF1B deletion syndrome Ru Kovvuri explains about her battle to get a diagnosis and support for her daughter who had multiple medical problems and learning difficulties as a result of a deletion of the HNF1B gene. Rhian Clissold discusses her research to improve the diagnosis of the HNF1B syndrome and recognise the associated learning difficulties seen with loss (deletion)  but not the spelling mistakes (mutations) in the HNF1B gene.

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]]> Ru Kovvuri explains about her battle to get a diagnosis and support for her daughter who had multiple medical problems and learning difficulties as a result of a deletion of the HNF1B gene. Rhian Clissold discusses her research to improve the diagnosis of the HNF1B syndrome and recognise the associated learning difficulties seen with loss (deletion)  but not the spelling mistakes (mutations) in the HNF1B gene.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16413112 Tue, 21 Jan 2025 09:00:00 +0000 2264 1in6b:3.9, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Ru Kovvuri, Rhian Clissold 3 9 full false Series 3 episode 8. HNF1Beta syndrome: kidney disease, diabetes, liver dysfunction and much more Series 3 episode 8. HNF1Beta syndrome: kidney disease, diabetes, liver dysfunction and much more Grant King talks about his diagnostic journey where his low birth weight, childhood kidney disease, diabetes, liver dysfunction and infertility were at 32 years finally recognised as all being due to a change in the HNF1Beta gene. Dr Coralie Bingham explains how her research during her PhD in Exeter led to HNF1Beta being established as the commonest cause of inherited kidney disease and all the key parts of the HNF1Beta syndrome being recognised.

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]]> Grant King talks about his diagnostic journey where his low birth weight, childhood kidney disease, diabetes, liver dysfunction and infertility were at 32 years finally recognised as all being due to a change in the HNF1Beta gene. Dr Coralie Bingham explains how her research during her PhD in Exeter led to HNF1Beta being established as the commonest cause of inherited kidney disease and all the key parts of the HNF1Beta syndrome being recognised.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16372342 Tue, 07 Jan 2025 09:00:00 +0000 2893 1in6b:3.8, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Tim Frayling, Rachel Freathy 3 8 full false Series 3 episode 7. Natalie Raphael and Alice Hughes Testing fetal genetics using mum’s blood in Glucokinase pregnancy Series 3 episode 7. Natalie Raphael and Alice Hughes Testing fetal genetics using mum’s blood in Glucokinase pregnancy Natalie Raphael was diagnosed as having glucokinase MODY at the end of her first pregnancy. In her second pregnancy she had a recently introduced blood test that showed her fetus had not inherited her change in the glucokinase gene so was at risk of growing large. As a result of this she was given long-acting insulin to lower her glucose.  Alice Hughes is the researcher who did the key study that proved the new blood test was both practical and accurate in glucokinase pregnancy.

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]]> Natalie Raphael was diagnosed as having glucokinase MODY at the end of her first pregnancy. In her second pregnancy she had a recently introduced blood test that showed her fetus had not inherited her change in the glucokinase gene so was at risk of growing large. As a result of this she was given long-acting insulin to lower her glucose.  Alice Hughes is the researcher who did the key study that proved the new blood test was both practical and accurate in glucokinase pregnancy.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16310659 Tue, 24 Dec 2024 09:00:00 +0000 2225 1in6b:3.7, diabetes, genetics, genes, andrew hattersley, Alice, Natalie 3 7 full false Series 3 episode 6. Gill Preston, Gill Spyer, and Ali Chakera The challenge of diagnosing and managing glucokinase MODY in pregnancy Series 3 episode 6. Gill Preston, Gill Spyer, and Ali Chakera The challenge of diagnosing and managing glucokinase MODY in pregnancy It was a great surprise for Gill Preston, who was active and slim, when she was diagnosed with gestational diabetes in her first pregnancy. Her raised fasting glucose did not come down with tablets or insulin. Luckily she met Andrew Hattersley in the diabetes pregnancy clinic, who recognised she had glucokinase MODY. Gill Spyer, working for her PhD as a research doctor showed that in glucokinase pregnancy the size of the baby depended on whether they inherited the genetic change from the mother and was not altered by insulin treatment. When the baby had the mutation it would grow normally and no treatment of the mother was needed. Ali Chakera continued research into glucokinase pregnancy; his research showed that slim women ( BMI <25) with a raised fasting glucose of above 5.5mmol/l had a 1 in 3 chance of having GCK MODY and should be tested. He also looked into genetic testing the fetus directly rather than trying to infer from fetal growth on ultrasound.

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]]> It was a great surprise for Gill Preston, who was active and slim, when she was diagnosed with gestational diabetes in her first pregnancy. Her raised fasting glucose did not come down with tablets or insulin. Luckily she met Andrew Hattersley in the diabetes pregnancy clinic, who recognised she had glucokinase MODY. Gill Spyer, working for her PhD as a research doctor showed that in glucokinase pregnancy the size of the baby depended on whether they inherited the genetic change from the mother and was not altered by insulin treatment. When the baby had the mutation it would grow normally and no treatment of the mother was needed. Ali Chakera continued research into glucokinase pregnancy; his research showed that slim women ( BMI <25) with a raised fasting glucose of above 5.5mmol/l had a 1 in 3 chance of having GCK MODY and should be tested. He also looked into genetic testing the fetus directly rather than trying to infer from fetal growth on ultrasound.

Send a text

]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16153036 Tue, 10 Dec 2024 09:00:00 +0000 2258 1in6b:3.6, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Ali, Gill, Gill 3 6 full false Series 3 episode 5. Andrew Lotery and Amanda Stride: Glucokinase MODY – a mildly raised fasting glucose for life that should not be treated Series 3 episode 5. Andrew Lotery and Amanda Stride: Glucokinase MODY – a mildly raised fasting glucose for life that should not be treated In this episode we talk to Andrew Lotery about how he was found to have a raised fasting glucose on an insurance medical. He was treated as Type 2 diabetes but he questioned this as he was young. slim and physically fit. A chance reading of a research funder’s newsletter led him to the Exeter team and a diagnosis of glucokinase MODY.  

Amanda Stride worked as a research registrar in Exeter.  She showed that in glucokinase MODY the fasting glucose was raised from birth and remained stable and regulated throughout life with treatment not changing the blood glucose. 

Anna Steele showed in her PhD that patients with glucokinase MODY did not get complications affecting the eye or kidney even after 50 years of raised glucose.  So in glucokinase MODY treatment with insulin or tablets is not needed and does not work; patients should be discharged and not followed up.


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]]> In this episode we talk to Andrew Lotery about how he was found to have a raised fasting glucose on an insurance medical. He was treated as Type 2 diabetes but he questioned this as he was young. slim and physically fit. A chance reading of a research funder’s newsletter led him to the Exeter team and a diagnosis of glucokinase MODY.  

Amanda Stride worked as a research registrar in Exeter.  She showed that in glucokinase MODY the fasting glucose was raised from birth and remained stable and regulated throughout life with treatment not changing the blood glucose. 

Anna Steele showed in her PhD that patients with glucokinase MODY did not get complications affecting the eye or kidney even after 50 years of raised glucose.  So in glucokinase MODY treatment with insulin or tablets is not needed and does not work; patients should be discharged and not followed up.


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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16153024 Tue, 26 Nov 2024 09:00:00 +0000 1958 1in6b:3.5, diabetes, genetics, genes, andrew hattersley, maggie shepherd, andrew lotery, amanda stride 2 5 full false Series 3 episode 4. Janette and Alice: Big babies with dangerously low blood sugars in HNF4A MODY Series 3 episode 4. Janette and Alice: Big babies with dangerously low blood sugars in HNF4A MODY In this episode we talk to Janette and her daughter Alice who were both correctly diagnosed with HNF4A MODY having been initially told they had Type 1 diabetes. The diagnosis not only allowed them to stop insulin but also explained the mystery of two of Jeanette’s children that were born as large babies and collapsed soon after birth with low blood sugar. Andrew explains how it was discovered that babies that inherited the HNF4A genetic change were on average over 800g heavier and were at high risk of low blood glucose around birth

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]]> In this episode we talk to Janette and her daughter Alice who were both correctly diagnosed with HNF4A MODY having been initially told they had Type 1 diabetes. The diagnosis not only allowed them to stop insulin but also explained the mystery of two of Jeanette’s children that were born as large babies and collapsed soon after birth with low blood sugar. Andrew explains how it was discovered that babies that inherited the HNF4A genetic change were on average over 800g heavier and were at high risk of low blood glucose around birth

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-16054270 Tue, 12 Nov 2024 09:00:00 +0000 2034 1in6b:3.4, diabetes, genetics, genes, andrew hattersley, maggie shepherd, alice, Jeanette 3 4 full false Series 3 episode 3. Mary Lee and Ewan Pearson: Finding the best treatment for HNF1A MODY Series 3 episode 3. Mary Lee and Ewan Pearson: Finding the best treatment for HNF1A MODY Mary Lee was thought to have Type 1 diabetes for over 3 decades; she was finally diagnosed with HNF1A MODY and was able to stop her insulin injections and get excellent blood sugar control with a sulphonylurea tablet.  We hear from Ewan Pearson how sulphonylurea tablets were found to be excellent glucose lowering treatment when Andrew’s clinical observations of his HNF1A MODY patients were followed up by Ewan with a clinical trial.

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]]> Mary Lee was thought to have Type 1 diabetes for over 3 decades; she was finally diagnosed with HNF1A MODY and was able to stop her insulin injections and get excellent blood sugar control with a sulphonylurea tablet.  We hear from Ewan Pearson how sulphonylurea tablets were found to be excellent glucose lowering treatment when Andrew’s clinical observations of his HNF1A MODY patients were followed up by Ewan with a clinical trial.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15975081 Tue, 29 Oct 2024 09:00:00 +0000 1668 1in6b:3.3, diabetes, genetics, genes, andrew hattersley, maggie shepherd,Mary, Ewan Pearson 3 3 full false Series 3 episode 2. Kevin Colclough and Bev Shields Making sure the right patients get the right genetic test for MODY Series 3 episode 2. Kevin Colclough and Bev Shields Making sure the right patients get the right genetic test for MODY Kevin Colclough describes how the genetic testing in diabetes has improved over the 2 decades he has worked in the Exeter NHS diagnostic lab.  His work means now over 60 types of single gene diabetes are looked for in one sequencing test. Bev Shields talks about how she developed the amazing MODY calculator that uses common clinical characteristics to work out how likely a person with diabetes is to have maturity onset diabetes of the young (MODY).

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]]> Kevin Colclough describes how the genetic testing in diabetes has improved over the 2 decades he has worked in the Exeter NHS diagnostic lab.  His work means now over 60 types of single gene diabetes are looked for in one sequencing test. Bev Shields talks about how she developed the amazing MODY calculator that uses common clinical characteristics to work out how likely a person with diabetes is to have maturity onset diabetes of the young (MODY).

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15812632 Tue, 15 Oct 2024 09:00:00 +0100 1585 1in6b:3.2, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Kevin Colclough, Bev Shields 3 2 full false Series 3 episode 1. Mary Humphries: The doctor didn’t listen! A delayed diagnosis of MODY Series 3 episode 1. Mary Humphries: The doctor didn’t listen! A delayed diagnosis of MODY Mary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin.  On insulin he had terrible problems with low blood sugars frequently losing consciousness and not managing to concentrate at school or at home.  Mary was very worried that he was getting worse on the insulin and asked about genetic tests because she had recently been diagnosed with Type 2 diabetes and there was diabetes in all generations of her family.  She was not listened to; the insulin was continued, and Dan got worse.  Searching the internet for answers she found the Exeter diabetesgenes.org website which led her to talking to Andrew and Maggie. 

They were able to rapidly diagnose that this was Maturity-onset Diabetes of the Young (MODY), subtype HNF1A . with a genetic test.   Maggie  helped Dan to stop his insulin and get excellent control on a quarter of the sulphonylurea tablet called gliclazide.  Dan rapidly improved off the insulin and passed his A levels with flying colours going to Bristol where he achieved his life’s ambition to become a large animal vet.  

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]]> Mary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin.  On insulin he had terrible problems with low blood sugars frequently losing consciousness and not managing to concentrate at school or at home.  Mary was very worried that he was getting worse on the insulin and asked about genetic tests because she had recently been diagnosed with Type 2 diabetes and there was diabetes in all generations of her family.  She was not listened to; the insulin was continued, and Dan got worse.  Searching the internet for answers she found the Exeter diabetesgenes.org website which led her to talking to Andrew and Maggie. 

They were able to rapidly diagnose that this was Maturity-onset Diabetes of the Young (MODY), subtype HNF1A . with a genetic test.   Maggie  helped Dan to stop his insulin and get excellent control on a quarter of the sulphonylurea tablet called gliclazide.  Dan rapidly improved off the insulin and passed his A levels with flying colours going to Bristol where he achieved his life’s ambition to become a large animal vet.  

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15806343 Tue, 01 Oct 2024 09:00:00 +0100 1741 1in6b:3.1, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Mary Humphries 3 1 full false Series 2 episode 9. Nick Thomas. Type 1 diabetes in the older adult Series 2 episode 9. Nick Thomas. Type 1 diabetes in the older adult Dr Nick Thomas talks about Type 1 diabetes in the older adult. In an iconoclastic study he showed most cases of Type 1 diabetes occur in adults rather than children. In older adults it is very hard to recognise as 98-99% of people with diabetes have Type 2 diabetes. Older adults with Type 1 diabetes have just as rapid a decline in their own insulin and need all the expert care offered to children. 

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]]> Dr Nick Thomas talks about Type 1 diabetes in the older adult. In an iconoclastic study he showed most cases of Type 1 diabetes occur in adults rather than children. In older adults it is very hard to recognise as 98-99% of people with diabetes have Type 2 diabetes. Older adults with Type 1 diabetes have just as rapid a decline in their own insulin and need all the expert care offered to children. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15727505 Tue, 17 Sep 2024 09:00:00 +0100 1444 1in6b:2.9, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Nick Thomas 2 9 full false Series 2 episode 8. Simon Goode and Angus Jones. Diagnosing Type 1 diabetes is difficult in older adults Series 2 episode 8. Simon Goode and Angus Jones. Diagnosing Type 1 diabetes is difficult in older adults Simon Goode was diagnosed with Type 2 diabetes aged 28.  He explains how it took 6 months of feeling unwell before it was realised he had Type 1 diabetes instead. Exeter Professor, Angus Jones, has done research showing that mistakes in the diagnosis Type of 1 diabetes are common in the older adult and offers solutions to help doctors get the diagnosis right. 

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]]> Simon Goode was diagnosed with Type 2 diabetes aged 28.  He explains how it took 6 months of feeling unwell before it was realised he had Type 1 diabetes instead. Exeter Professor, Angus Jones, has done research showing that mistakes in the diagnosis Type of 1 diabetes are common in the older adult and offers solutions to help doctors get the diagnosis right. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15681144 Tue, 03 Sep 2024 09:00:00 +0100 2337 1in6b:2.8, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Simon Goode, Angus Jones 2 8 full false Series 2 Episode 7. Jean Claude Katte. Type 1 Diabetes in Africa: different in so many ways. Series 2 Episode 7. Jean Claude Katte. Type 1 Diabetes in Africa: different in so many ways. Dr Jean Claude Katte explains how in Sub Saharan Africa diagnosis, treatment and monitoring of Type 1 diabetes in children and young adults is so much harder than in Europe.  He discusses with Maggie and Andrew his own exciting research that has shown that around 60% of African children with diabetes do not have the typical autoimmune Type 1 diabetes seen in over 90% of children with diabetes in Europe. Jean Claude aims to do more research to discover what causes this new cause of severe young-onset diabetes in Sub Saharan Africa.

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]]> Dr Jean Claude Katte explains how in Sub Saharan Africa diagnosis, treatment and monitoring of Type 1 diabetes in children and young adults is so much harder than in Europe.  He discusses with Maggie and Andrew his own exciting research that has shown that around 60% of African children with diabetes do not have the typical autoimmune Type 1 diabetes seen in over 90% of children with diabetes in Europe. Jean Claude aims to do more research to discover what causes this new cause of severe young-onset diabetes in Sub Saharan Africa.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15604416 Tue, 20 Aug 2024 09:00:00 +0100 2145 1in6b:2.7, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Jean Claude Katte, Africa 2 7 full false Series 2 episode 6. Mendy Korer and Matt Johnson. Type 1 diabetes in very young children: a massive challenge for families and scientists Series 2 episode 6. Mendy Korer and Matt Johnson. Type 1 diabetes in very young children: a massive challenge for families and scientists We hear from Mendy Korer about the enormous challenges of living with a child who was diagnosed with Type 1 diabetes aged 11 months. Matt Johnson, a research fellow in Exeter talks about his exciting work understanding what makes the immune system destroy the insulin making beta-cells in very young children. 

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]]> We hear from Mendy Korer about the enormous challenges of living with a child who was diagnosed with Type 1 diabetes aged 11 months. Matt Johnson, a research fellow in Exeter talks about his exciting work understanding what makes the immune system destroy the insulin making beta-cells in very young children. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15531848 Tue, 06 Aug 2024 09:00:00 +0100 2855 1in6b:2.6, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Mendy Korer, Matt Johnson 2 6 full false Series 2 Episode 5. Richard Oram . Genius genetics improves diagnosis and prevention of Type 1 diabetes Series 2 Episode 5. Richard Oram . Genius genetics improves diagnosis and prevention of Type 1 diabetes Professor Richard Oram had the innovative idea of turning complex analysis of the genetic changes  into a single number that estimate the likelihood of developing Type 1 diabetes. He explains to Andrew and Maggie how this has helped diagnosis of Type 1 diabetes and is being used around the world in studies aiming to prevent or delay diabetes in children.

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]]> Professor Richard Oram had the innovative idea of turning complex analysis of the genetic changes  into a single number that estimate the likelihood of developing Type 1 diabetes. He explains to Andrew and Maggie how this has helped diagnosis of Type 1 diabetes and is being used around the world in studies aiming to prevent or delay diabetes in children.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15448403 Tue, 23 Jul 2024 09:00:00 +0100 1798 1in6b:2.5, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Richard Oram 2 5 full false Series 2 Episode 4. Partha Kar. The super hero who made sure Type 1 diabetes technology was for everyone Series 2 Episode 4. Partha Kar. The super hero who made sure Type 1 diabetes technology was for everyone Professor Partha Kar has made sure the technical advances in measuring blood sugar are available to everyone living with Type 1 diabetes in the UK.  Partha had to overcame massive hurdles to make sure the technology was not just available to a privileged few. He discusses with Maggie and Andrew his inspirational leadership style and philosophy that have helped him to move mountains in the NHS.

Vote for One in Six Billion in the British Podcast Awards: https://www.britishpodcastawards.com/voting

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]]> Professor Partha Kar has made sure the technical advances in measuring blood sugar are available to everyone living with Type 1 diabetes in the UK.  Partha had to overcame massive hurdles to make sure the technology was not just available to a privileged few. He discusses with Maggie and Andrew his inspirational leadership style and philosophy that have helped him to move mountains in the NHS.

Vote for One in Six Billion in the British Podcast Awards: https://www.britishpodcastawards.com/voting

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15356757 Tue, 09 Jul 2024 09:00:00 +0100 2451 1in6b:2.4, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Partha Kar 2 4 full false Series 2 Episode 3. Jean Dudderidge and Jill Epton. Living with Type 1 diabetes for over 50 years. Series 2 Episode 3. Jean Dudderidge and Jill Epton. Living with Type 1 diabetes for over 50 years. Jean Dudderidge and Jill Epton talk about what it has been like to live with Type 1 diabetes for over 50 years. They discuss the massive advances in the measurement of blood sugar over the decades and how they now benefit greatly from continuous glucose monitoring.

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]]> Jean Dudderidge and Jill Epton talk about what it has been like to live with Type 1 diabetes for over 50 years. They discuss the massive advances in the measurement of blood sugar over the decades and how they now benefit greatly from continuous glucose monitoring.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15300477 Tue, 25 Jun 2024 09:00:00 +0100 1986 1in6b:2.3, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Jill Epton, Jean Dudderidge 2 3 full false Series 2 Episode 2. Moira Murphy and Mark McCarthy. Defining the genetic susceptibility to Type 2 diabetes Series 2 Episode 2. Moira Murphy and Mark McCarthy. Defining the genetic susceptibility to Type 2 diabetes Moira Murphy and Mark McCarthy talk about how a unified UK team of scientists came to be world leaders in decoding the genetic susceptibility to Type 2 diabetes.

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]]> Moira Murphy and Mark McCarthy talk about how a unified UK team of scientists came to be world leaders in decoding the genetic susceptibility to Type 2 diabetes.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15219253 Tue, 11 Jun 2024 09:00:00 +0100 2701 1in6b:2.2, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Moira Murphy, Mark McCarthy 2 2 full false Series 2 Episode 1. Tim Frayling and Rachel Freathy. Finding the Fat gene Series 2 Episode 1. Tim Frayling and Rachel Freathy. Finding the Fat gene We talk to Tim Frayling and Rachel Freathy about how they discovered the “Fat gene”.  Working with Oxford, the Exeter team showed a genetic change near FTO predisposed to obesity. This was the first and largest common genetic change altering weight.

 

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]]> We talk to Tim Frayling and Rachel Freathy about how they discovered the “Fat gene”.  Working with Oxford, the Exeter team showed a genetic change near FTO predisposed to obesity. This was the first and largest common genetic change altering weight.

 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15072195 Tue, 28 May 2024 09:00:00 +0100 1492 1in6b:2.1, diabetes, genetics, genes, andrew hattersley, maggie shepherd, Tim Frayling, Rachel Freathy 2 1 full false Special episode 4. Tim Frayling – From PhD student to internationally famous polygenic team leader Special episode 4. Tim Frayling – From PhD student to internationally famous polygenic team leader In this special episode, we hear from Professor Tim Frayling who was Andrew and Sian’s first PhD student in 1995. He rapidly became the head of the analysis for the genetic susceptibility for Type 2 diabetes.  His leadership has made Exeter an international leader in polygenic trait genetics.

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]]> In this special episode, we hear from Professor Tim Frayling who was Andrew and Sian’s first PhD student in 1995. He rapidly became the head of the analysis for the genetic susceptibility for Type 2 diabetes.  His leadership has made Exeter an international leader in polygenic trait genetics.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-15007140 Tue, 14 May 2024 09:00:00 +0100 1905 diabetes, special 4, genetics, genes, andrew hattersley, maggie shepherd, Tim Frayling, diabetes 1 bonus false Special episode 3. Sian Ellard – establishing a world leading genetics lab from scratch Special episode 3. Sian Ellard – establishing a world leading genetics lab from scratch In this special episode, we hear from Professor Sian Ellard who, like Andrew and Maggie, started in Exeter in 1995.  Sian set up the Exeter molecular genetics laboratory from scratch.  Through Sian’s leadership, this laboratory became world leading for both research and NHS diagnostic testing.

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]]> In this special episode, we hear from Professor Sian Ellard who, like Andrew and Maggie, started in Exeter in 1995.  Sian set up the Exeter molecular genetics laboratory from scratch.  Through Sian’s leadership, this laboratory became world leading for both research and NHS diagnostic testing.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14927242 Tue, 30 Apr 2024 10:00:00 +0100 2550 diabetes, special 3, genetics, genes, andrew hattersley, maggie shepherd, Sian Ellard, neonatal diabetes 1 bonus false Series 1 Episode 10: Imran Bashir and Elisa De Franco –the epic human and scientific journeys after a girl was born without a pancreas Series 1 Episode 10: Imran Bashir and Elisa De Franco –the epic human and scientific journeys after a girl was born without a pancreas In this episode, Maggie and Andrew talk to Imran Bashir about the difficult journey he and his family have been on since his daughter was born without a pancreas.  They also hear from star scientist Dr Elisa De Franco about the long and challenging scientific journey to solve the genetic mystery of why her pancreas did not develop.

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]]> In this episode, Maggie and Andrew talk to Imran Bashir about the difficult journey he and his family have been on since his daughter was born without a pancreas.  They also hear from star scientist Dr Elisa De Franco about the long and challenging scientific journey to solve the genetic mystery of why her pancreas did not develop.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14765685 Tue, 16 Apr 2024 09:00:00 +0100 2802 diabetes, episode ten, genetics, genes, andrew hattersley, maggie shepherd, Imran Bashir, Tanya Bashir, Elisa De Franco, neonatal diabetes 1 10 full false Series 1 Episode 9: Elisa De Franco –the world leading gene discoverer Series 1 Episode 9: Elisa De Franco –the world leading gene discoverer In this episode, Maggie and Andrew talk to Dr Elisa De Franco, the Exeter based genetic scientist whose research has discovered more genetic causes of diabetes than anyone else in the world.

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]]> In this episode, Maggie and Andrew talk to Dr Elisa De Franco, the Exeter based genetic scientist whose research has discovered more genetic causes of diabetes than anyone else in the world.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14407101 Tue, 02 Apr 2024 09:00:00 +0100 1660 diabetes, episode nine, genetics, genes, andrew hattersley, maggie shepherd, Elisa de Franco, neonatal diabetes full false Special episode 2: Maggie Shepherd - The journey to a career in Diabetes Research Special episode 2: Maggie Shepherd - The journey to a career in Diabetes Research In this special episode Andrew Hattersley talks with co-presenter Maggie Shepherd to identify what led to her joining the Exeter team in 1995 and ending up becoming the leading nurse for monogenic diabetes with a role combining clinical care, research and education 

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]]> In this special episode Andrew Hattersley talks with co-presenter Maggie Shepherd to identify what led to her joining the Exeter team in 1995 and ending up becoming the leading nurse for monogenic diabetes with a role combining clinical care, research and education 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14407193 Tue, 19 Mar 2024 09:00:00 +0000 1646 diabetes, special two, genetics, genes, andrew hattersley, maggie shepherd, neonatal diabetes 1 0 bonus false Series 1 Episode 8: Carsyn Underwood, Karla Underwood, Donna Taylor and Tim McDonald. Early correct treatment is excellent! How can we treat everyone early? Series 1 Episode 8: Carsyn Underwood, Karla Underwood, Donna Taylor and Tim McDonald. Early correct treatment is excellent! How can we treat everyone early? In this episode, Maggie and Andrew start by talking to Carsyn Underwood and her mums Karla and Donna about Carsyn’s diagnosis of neonatal diabetes and how she got the right treatment very early and had an the excellent outcome as a result,.  

They go on to talk to Professor Tim McDonald, a top NHS laboratory scientist, who has been researching into how we can make sure everyone is diagnosed early by developing universal screening for neonatal diabetes in the first week of life.

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]]> In this episode, Maggie and Andrew start by talking to Carsyn Underwood and her mums Karla and Donna about Carsyn’s diagnosis of neonatal diabetes and how she got the right treatment very early and had an the excellent outcome as a result,.  

They go on to talk to Professor Tim McDonald, a top NHS laboratory scientist, who has been researching into how we can make sure everyone is diagnosed early by developing universal screening for neonatal diabetes in the first week of life.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14407078 Tue, 05 Mar 2024 09:00:00 +0000 2636 diabetes, episode eight, genetics, genes, andrew hattersley, maggie shepherd, Tim McDonald, Carsyn Underwood, neonatal diabetes 1 8 full false Series 1 Episode 7: Pam Bowman – writing the next chapter in neonatal diabetes Series 1 Episode 7: Pam Bowman – writing the next chapter in neonatal diabetes In this episode, Maggie and Andrew talk to Dr Pam Bowman, the doctor scientist, whose research has greatly advanced our understanding of neonatal diabetes. Pam showed treatment with sulphonylurea tablets control the glucose excellently in the long term and she transformed our understanding of how thinking, and development are altered by the change in the potassium channel gene.

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]]> In this episode, Maggie and Andrew talk to Dr Pam Bowman, the doctor scientist, whose research has greatly advanced our understanding of neonatal diabetes. Pam showed treatment with sulphonylurea tablets control the glucose excellently in the long term and she transformed our understanding of how thinking, and development are altered by the change in the potassium channel gene.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14407067 Tue, 20 Feb 2024 09:00:00 +0000 1489 diabetes, episode seven, genetics, genes, andrew hattersley, maggie shepherd, Pam Bowman, neonatal diabetes 1 7 full false Series 1 Episode 6: Dame Frances Ashcroft – scientist extraordinaire! Series 1 Episode 6: Dame Frances Ashcroft – scientist extraordinaire! In this episode Maggie and Andrew talk to Dame Frances Ashcroft the remarkable Oxford scientist who has dedicated her life to understanding the key role of potassium channel in insulin secretion by the pancreatic beta-cell.  Her work was crucial both before and after the Exeter genetic discovery in neonatal diabetes


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]]> In this episode Maggie and Andrew talk to Dame Frances Ashcroft the remarkable Oxford scientist who has dedicated her life to understanding the key role of potassium channel in insulin secretion by the pancreatic beta-cell.  Her work was crucial both before and after the Exeter genetic discovery in neonatal diabetes


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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14325348 Tue, 06 Feb 2024 09:00:00 +0000 2317 diabetes, episode six, genetics, genes, andrew hattersley, maggie shepherd, Dame Frances Ashcroft, neonatal diabetes 1 6 full false Series 1 Episode 5: Laurie and Mike Jaffe: Spreading the word (USA) Series 1 Episode 5: Laurie and Mike Jaffe: Spreading the word (USA) In this episode, we hear from Laurie and Mike Jaffe from Chicago, USA.  They spread the word about neonatal diabetes to over 100M people around the world by an inspirational media campaign focused on their daughter, Lilly and how the diagnosis and resulting treatment change transformed her life. 

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]]> In this episode, we hear from Laurie and Mike Jaffe from Chicago, USA.  They spread the word about neonatal diabetes to over 100M people around the world by an inspirational media campaign focused on their daughter, Lilly and how the diagnosis and resulting treatment change transformed her life. 

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14290264 Tue, 23 Jan 2024 09:00:00 +0000 1635 diabetes, episode five, genetics, genes, andrew hattersley, maggie shepherd, Mike Jaffe, Lorir Jaffe, neonatal diabetes 1 5 full false Series 1 Episode 4: Agnes Graja & Helen John – spreading the word (UK) Series 1 Episode 4: Agnes Graja & Helen John – spreading the word (UK) In this episode we hear from Agnes Graja and Helen John, two of the national team of Genetic Diabetes Nurses that spread the news about neonatal diabetes across the UK. They identified and improved treatment in insulin-treated adults who had been diagnosed with diabetes in the first 6 months of life.

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]]> In this episode we hear from Agnes Graja and Helen John, two of the national team of Genetic Diabetes Nurses that spread the news about neonatal diabetes across the UK. They identified and improved treatment in insulin-treated adults who had been diagnosed with diabetes in the first 6 months of life.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14270125 Tue, 09 Jan 2024 09:00:00 +0000 1925 diabetes, episode four, genetics, genes, andrew hattersley, maggie shepherd, Agnes Graja, Helen John, neonatal diabetes 1 4 full false Special episode 1 : Andrew Hattersley - The journey to a career in Diabetes Research Special episode 1 : Andrew Hattersley - The journey to a career in Diabetes Research In this special episode Maggie Shepherd talks with co-presenter Andrew Hattersley exploring what led to him ending up as a research scientist and diabetes consultant in Exeter in 1995.  They go back into how he became a doctor and what took him into research including surprising revelations about a transformative time in Africa as an 18-year-old!  

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]]> In this special episode Maggie Shepherd talks with co-presenter Andrew Hattersley exploring what led to him ending up as a research scientist and diabetes consultant in Exeter in 1995.  They go back into how he became a doctor and what took him into research including surprising revelations about a transformative time in Africa as an 18-year-old!  

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14193341 Tue, 26 Dec 2023 09:00:00 +0000 2051 diabetes, special one, genetics, genes, andrew hattersley, maggie shepherd 1 0 bonus false Series 1 Episode 3: Ewan Pearson - an unexpected and remarkable treatment Series 1 Episode 3: Ewan Pearson - an unexpected and remarkable treatment In this episode we hear about how sulphonylurea tablets were discovered to be an unexpected. and remarkably effective, new treatment for neonatal diabetes. 

Maggie and Andrew talk to Professor Ewan Pearson, the  doctor scientist, who worked with doctors around the world to prove how good this treatment was and how it worked.

More on www.1in6b.com

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]]> In this episode we hear about how sulphonylurea tablets were discovered to be an unexpected. and remarkably effective, new treatment for neonatal diabetes. 

Maggie and Andrew talk to Professor Ewan Pearson, the  doctor scientist, who worked with doctors around the world to prove how good this treatment was and how it worked.

More on www.1in6b.com

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14119768 Tue, 12 Dec 2023 09:00:00 +0000 2185 diabetes, episode three, genetics, genes, andrew hattersley, maggie shepherd, Ewan Pearson 1 3 full false Series 1 Episode 2: Anna Gloyn - the gene detective Series 1 Episode 2: Anna Gloyn - the gene detective In this episode Maggie and Andrew talk to Anna Gloyn, the  scientist who discovered the gene that was altered when very young babies were diagnosed with neonatal diabetes.  


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]]> In this episode Maggie and Andrew talk to Anna Gloyn, the  scientist who discovered the gene that was altered when very young babies were diagnosed with neonatal diabetes.  


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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-14042082 Tue, 28 Nov 2023 09:00:00 +0000 2234 diabetes,episode two, genetics, genes, andrew hattersley, maggie shepherd, Anna Gloyn the gene detective 1 2 full false Series 1 Episode 1: Jack - a life transformed Series 1 Episode 1: Jack - a life transformed In this episode Andrew and Maggie are joined by Emma Matthews. Emma talks about her son Jack who was diagnosed with diabetes when 2 weeks old. Jack’s life was transformed when a genetic cause was found for his diabetes.

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]]> In this episode Andrew and Maggie are joined by Emma Matthews. Emma talks about her son Jack who was diagnosed with diabetes when 2 weeks old. Jack’s life was transformed when a genetic cause was found for his diabetes.

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]]> Andrew Hattersley and Maggie Shepherd Buzzsprout-13939230 Mon, 13 Nov 2023 10:00:00 +0000 3500 diabetes, episode one, genetics, genes, andrew hattersley, maggie shepherd, Jack - a life transformed 1 1 full false