Cobenfy doesn't block dopamine — and that's the whole point. In this special episode, we step away from the bipolar just a bit to unpack the first genuinely new mechanism in schizophrenia treatment in decades. We break down how Cobenfy pairs xanomeline (a brain-penetrant M1/M4 muscarinic agonist) with trospium (a peripheral blocker that curbs the side effects), trace its surprising betel-nut origins, and explain the why behind the how: quieting dopamine in the striatum for positive symptoms and boosting GABA in the prefrontal cortex for cognition — all without the D2 blockade that brings EPS, weight gain, and sedation.

https://www.nguyenindoubt.com/theyinpsych
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We're now tracing how dopamine and serotonin imbalances map onto psychomotor agitation, depression, and that “too much energy” feel of mania. We also stop by the basal ganglia–thalamus–sensorimotor loop, the ventrolateral and ventromedial prefrontal cortex, the amygdala, and the superior frontal gyrus to show how disrupted circuits drive impulsivity, hyperemotionality, and goal-directed behavior. Say that 10 times.

https://www.nguyenindoubt.com/theyinpsych
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All aboard the Bipolar Express to unpack one of the messiest puzzles in psych: why diagnosing Bipolar Disorder sometimes feels like trying to solve a Rubik’s cube — when there could also be ADHD, anxiety, personality disorders, substance use, sleep-issues, or even childhood trauma riding shotgun. 

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We make a tokyo drift to a new topic: bipolarism! Lets jump in and manically (responsibly) get through as much as we can with depression and its interfaces. 

Hope you brought your shovel cause we're about to DIGFAST.

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It never gets old to talk about late-life depression. Lets explore why growing older can sometimes mean growing sadder.

We prance through executive dysfunction, vascular woes, inflammatory fires, and amyloid beta blues. 

We’ll discuss why SSRIs might not be the golden ticket and what alternatives, like dopamine agonists, rTMS, and even ECT, can brighten those grey years.

Plus, we'll ponder if your patient is depressed, or if their brain is just throwing a vascular tantrum.

Tune in, turn up your hearing aids, and fluid restrict for the next 20 minutes if you have the worlds smallest bladder.

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Lets do the discussion tango between the liver and psychotrops: today we're focusing on patients with cirrhosis. Discussing 1st-pass metabolism, phase 1 and 2 metabolisms, plasma protein binding, fluid overload, and the implications of these processes on medication efficacy and toxicity.

We know you liver this stuff.

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Lets explore the kidneys in psychiatry and discuss the impact of renal disease on medication management. No kidding these kidneys can be curiously be essential to know about for psychiatry.

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Explore the intersection of depression and neurocognitive disorders in elderly patients. The discussion highlights the challenges in differentiating between depression and apathy, the importance of accurate diagnosis, and the appropriate pharmacological considerations for treatment. 

Don't forget to listen to this episode on your geriatrics rotation.

https://www.nguyenindoubt.com/theyinpsych
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A continuation of Part one of potentially potent side effects of SSRIs - we now dive into the dark yet enlightening side effects of conventional antidepressants. From weight gain to sexual side effects and hyponatremia.

Please dose this episode PRN throughout your career.

https://www.nguyenindoubt.com/theyinpsych
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We explore the potentially potent side effects of SSRIs. This includes the risks of switching to mania, the role of mood stabilizers, the increased risk of suicidality in younger patients, and the common side effects of nausea and vomiting.

This episode pairs well with some chamomille and a nice view.

https://www.nguyenindoubt.com/theyinpsych
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When the algorithm for treating depression runs out of runway, we'll come to your aid with this podcast.

Tune in as we briefly review the treatments reserved for the refractive cases of depression.

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I hope you're in business casual, whatever that means, and join us this evening for a soiree that will give Bridgerton a run for its money. Okay not really but we only hope -especially when we'll be jiving to the conversation of fluoxetine and fluvoxamine: the twins of SSRIs that never were.

Got that beverage ready yet for this episode?

Good.

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Review with us the first line agents when considering psychopharmacology for your patients. The granular details can be daunting sometimes, but at the very least they'll help you be aware of some cautionary contexts, build your psychopharm database for that next test, or just flex when at your next noon conference ;).

https://www.nguyenindoubt.com/theyinpsych
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Nonpharmacologic treatment options for depression and our options of holistic approaches, therapies, and lifestyle changes that offer powerful tools for managing and overcoming this challenge.

Learn how small changes in your patients routine can have a profound impact on their mental well being.

https://www.nguyenindoubt.com/theyinpsych
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Lets talk about the do’s and don’ts of depression.

They discuss everything from why we need to treat it, how to diagnose it, and its different treatment modalities. Depression decisions need to be made and this podcast can help you make them! 

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Trek through the landscape of vortioxetine via neurotransmitters, GABA interneurons, and serotonin receptors, all with the goal of making this complex antidepressant understandable.

The hosts' accents might challenge your ears, but their insights will stimulate your brain. Maybe the audio engineer just needs to be better.

This episode is chock-full of wit, laughs, and unexpected revelations about vortioxetine's potential benefits in cognitive dysfunction and its low sexual side effects.

https://www.nguyenindoubt.com/theyinpsych
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We jump into antidepressants.

We unravel the enigma surrounding antidepressants, delving into how they work in the brain and why they can take time to have an effect. Discover the hidden mechanisms and uncover the secrets behind these transformative treatments.

Feel uplifted with this episode.

https://www.nguyenindoubt.com/theyinpsych
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We heard your feedback and decided to introduce another trailer with a little bit more background on the hosts behind the podcast. Be sure to check it out and give us some kudos, or hopefully some constructive feedback.

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Join our whirlwind tour in the moody labyrinth of depression on "The Y in Psychiatry". This is not your a usual clinical field trip - it's a rollercoaster ride through brain inheritance battles, medical conundrums, and psychosocial puppetry. We shine the neuro-flashlight onto the salience, executive, and default mode networks, making sense of the science, symptoms, and synaptic circus of depression.

Buckle up and bring your sense of humor.

https://www.nguyenindoubt.com/theyinpsych
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Who are we? Y, we're glad you asked.

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And further in our antidepressant journey we find out what the buzz around ketamine is all about. 

Listen to us discuss the use of ketamine in the treatment of depression. Explore everything from its receptors in the brain, why it works so fast, and why psychiatrists may be turning to this in their everyday practice.

Tune in to find out what’s so special about Special K. 

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