Dr. Journal Club

Mistletoe in Oncology: A Deep Dive into Pancreatic Cancer Trials

Thu, 01 Aug 2024 12:00:00 -0400

Could mistletoe be the unexpected key to fighting advanced pancreatic cancer? Join us as we explore the research behind mistletoe extract, Viscum album, and its potential in oncology. We'll delve into the MISTRAL trial, highlighting the herb's immunomodulating and anti-inflammatory properties, administration methods, and injection site reactions. We also critically examine the MAPAC trial, emphasizing the need for rigorous research in life-threatening conditions.

Tune in for an engaging discussion on the placebo-controlled trial evaluating mistletoe as an adjunct therapy for advanced exocrine pancreatic cancer. We'll break down the trial's design, challenges in maintaining blinding, participant functionality scores, and exclusion criteria. Our analysis includes comparing results with previous studies, geographic variations in end-of-life care, and the ceiling effect. Gain insights into mistletoe's safety and interaction with chemotherapy, and learn why well-conducted trials with negative outcomes are crucial for medical advancement. Don't miss this episode on integrating new interventions into clinical practice.

https://pubmed.ncbi.nlm.nih.gov/38915151/

Wode K, Kienle GS, Björ O, Fransson P, Sharp L, Elander NO, Bernhardson BM, Johansson B, Edwinsdotter Ardnor C, Scheibling U, Hök Nordberg J, Henriksson R. Mistletoe Extract in Patients With Advanced Pancreatic Cancer. Dtsch Arztebl Int. 2024 May 31;121(11):347-354. doi: 10.3238/arztebl.m2024.0080. PMID: 38915151.

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Secondhand Smoke and Vaping's Impact on Children

Fri, 26 Jul 2024 01:00:00 -0400

In this episode of the Dr Journal Club podcast, we reveal the alarming statistic that one in five children are still exposed to secondhand smoke despite declining smoking rates. We dive into the differences between mainstream and sidestream smoke, explore vaping's unique mechanisms that retain 99% of nicotine, and analyze a study on nicotine absorption in children.

We also discuss the reliability of observational studies on smoking and vaping habits, highlighting the biases that can affect results, such as social desirability bias. Measuring genuine exposure levels, especially when parents smoke indoors, presents complex challenges that we scrutinize in depth.

Join us for critical insights and ethical considerations on this pressing issue. Connect with us on social media at DrJournalClub to share your thoughts and questions. Be part of our mission to explore evidence-based integrative medicine and improve public health.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821086

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N-Acetylcysteine for Endometriosis: An Integrative Medicine Review

Thu, 18 Jul 2024 13:00:00 -0400

Ever wondered if a common supplement could help with endometriosis pain? In our latest episode, we dive into a listener-requested discussion on N-acetylcysteine (NAC). We explore NAC's potential to manage endometriosis-related pain, reduce endometrioma size, and improve fertility.

https://pubmed.ncbi.nlm.nih.gov/36981595/

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Osteoporosis Treatment Options: A Super Speedy Review

Fri, 12 Jul 2024 12:00:00 -0400

Unlock the secrets to effective osteoporosis treatment in this super speedy review from the Dr Journal Club podcast. Dr. Joshua Goldenberg highlights key medications from a recent BMJ systematic review and network meta-analysis. Discover why PTH agonists are the most effective for preventing clinical fractures in postmenopausal women and see how other medications compare.

With over 80,000 women in 69 randomized controlled trials, the study offers crucial insights into the efficacy and safety of various osteoporosis medications, with no significant harm outcomes reported. Whether you're a healthcare professional or a concerned family member, this episode is packed with valuable information. Don't miss the basic and in-depth versions of the review available on our platform!

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Evaluating the Impact of Multivitamins on Health and Longevity

Thu, 04 Jul 2024 12:00:00 -0400

Can multivitamins extend your lifespan or are they just giving you "expensive urine"? Join Josh and Adam in this Dr Journal Club podcast episode as they dive into a revealing JAMA Network Open study, exploring the true impact of multivitamin use on mortality risk. With 30% of the population regularly consuming these supplements, understanding their real benefits and potential harms is crucial.

In this episode, we break down the study's analysis of data from three prospective US cohorts to answer whether multivitamins truly prevent all-cause mortality, cancer, and cardiovascular disease.

Tune in for a critical evaluation of this popular health practice and see if multivitamins are truly worth the hype.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820369

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Understanding Smoking Cessation: E-Cigarettes and Chantix

Thu, 27 Jun 2024 13:00:00 -0400

In this episode, we dive into the complex narrative of electronic cigarettes and their role in smoking cessation. Join Josh and Adam as they review research showing e-cigarettes as safer than traditional cigarettes in terms of chemical exposure while also examining the risks for non-smokers.

We present evidence that nicotine e-cigarettes may outperform traditional nicotine replacement therapies like patches and gums. Supported by sources such as the American Journal of Public Health and Cochrane, we compare e-cigarettes with Chantix (varenicline) for smoking cessation. We highlight clinical outcomes and the under-researched long-term side effects of e-cigarettes.

Engage with us on social media and share your thoughts and suggestions for future episodes. Thank you for joining the Doctor Journal Club podcast!

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Milk, BLV, and Breast Cancer: Unraveling the Controversy

Thu, 13 Jun 2024 16:00:00 -0400

Can drinking milk potentially increase your risk of breast cancer? Join us as we explore the controversial link between bovine leukemia virus (BLV) in milk and breast cancer risk. Sparked by a patient’s concern and a meta-analysis review, this episode emphasizes the importance of asking detailed questions in understanding scientific research.

We critically examine a meta-analysis on BLV and breast cancer, uncovering significant methodological flaws, from lack of pre-registration to biased selection criteria. Our discussion highlights the need for intellectual honesty and rigorous scrutiny in healthcare research.

We also question the credibility of the systematic review, pointing out the drastic reduction of eligible studies and the peer review process's legitimacy. By discussing the 2.57 odds ratio of BLV's association with breast cancer and the difference between correlation and causation, we aim to provide a comprehensive understanding of the challenges in interpreting scientific research. Tune in to gain insights into the complexities of medical studies and the importance of critical appraisal in healthcare.

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Avoiding Ultra-Processed Foods: A Deep Dive into Health Impacts and Research Insights

Fri, 07 Jun 2024 00:00:00 -0400

Can avoiding certain foods extend your life? This episode explores a recent BMJ paper on diet and health, focusing on ultra-processed foods and their hidden calories. It highlights the links between these foods and obesity, cardiovascular disease, diabetes, and cancer.

Insights from major studies, like the Nurses' Health Study and the Health Professional Follow-Up Study, show how socioeconomic factors and healthcare professionals' behaviors influence outcomes. The discussion also addresses the importance of accurate food intake data and the challenges of long-term studies.

This engaging discussion aims to provide valuable perspectives on navigating evidence-based integrative medicine and making informed dietary choices for better health.

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Krill Oil for Knee Osteoarthritis: A Deep Dive into the Research

Thu, 30 May 2024 10:00:00 -0400

What can we learn from the latest research on krill oil's effects on knee osteoarthritis? We dive deep into the study's transparency and rigor, exploring the impact of adherence rates and the significance of measurable markers like effusion synovitis. Our spirited debate covers biases in healthcare, the balance between skepticism and openness to new evidence, and the emotional responses tied to negative trial outcomes. This episode is packed with thoughtful reflections and expert insights, making it essential listening for anyone interested in evidence-based integrative medicine. Tune in for a comprehensive and engaging exploration of the complexities of clinical trials!

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Navigating Nutrition's Role in Combating Depression

Thu, 23 May 2024 00:00:00 -0400

Are your food choices influencing your mood? Uncover the startling connections between your diet and your mental well-being as we scrutinize a pivotal study from BMC Psychiatry. Delve into the realm of low-grade chronic inflammation and its potential role in depression, with a special focus on healthcare professionals. We dissect the use of the innovative Empirical Dietary Inflammatory Index (EDII) and how it could revolutionize your approach to combatting depressive symptoms through diet.

Join the conversation with us, Dr Journal Club, as we navigate the latest in research and evidence-based medicine, integrating thinkers at the forefront of clinical practice. Your input is vital to our discussions, so link up with us on social platforms and share your thoughts on this complex topic. Whether you're seeking to refine your clinical practice or simply curious about the impact of diet on mental health, this episode promises insights that could very well reshape your daily habits.

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A Super Speedy Review: The MIND Diet

Thu, 16 May 2024 10:00:00 -0400

Ready for a quick dive into the connection between diet and cognitive health? In this Doctor Journal Club Podcast episode, Dr. Joshua Goldenberg swiftly unpacks the Mind Diet Trial for dementia, a major study from 2023. Discover why a Mediterranean and Dash-inspired diet in high-risk elderly adults didn't show significant cognitive differences. Dr. Goldenberg's rapid analysis gives you a speedy overview of Alzheimer's prevention. Plus, catch tips on evaluating medical literature and a glimpse into our EBM Boot Camp for clinicians. Get set for a fast-paced journey into medical research and eye-opening insights!

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Probiotics and Mental Health

Thu, 09 May 2024 10:00:00 -0400

Join Dr. Joshua Goldenberg on the Dr. Journal Club podcast for a quick dive into probiotics and their impact on mental health. Uncover the latest research linking probiotics to symptom reduction and inflammation relief, while exploring potential pathways for enhancing mental well-being and innovative approaches to integrative mental health care. Tune in for rapid insights and compassionate discussions on healing. Remember, always consult a healthcare professional for personalized medical advice.

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Super Speedy Summary: Medical Cannabis Trials for Pain

Thu, 02 May 2024 10:00:00 -0400

Join Dr. Goldenberg for this super speedy summary, which takes a peak into the evolving role of medical cannabis in chronic pain management, as discussed by Dr. Jamie Caroon, a prominent figure in CBD and cannabis research. Focusing on a recent BMJ clinical practice guideline, Dr. Caroon's insights challenge conventional views, emphasizing the need for cautious consideration of medical cannabis trials. Despite varied recommendations, the guideline highlights modest yet significant benefits in high-quality evidence. This discussion underscores the importance of evidence-based approaches in navigating the complexities of pain management and medical cannabis usage.

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Bone Health: Shilajit's Benefits for Women

Thu, 25 Apr 2024 10:00:00 -0400

Join Josh and Adam as they delve into a captivating study on the Ayurvedic remedy Shilajit, uncovering its potential in addressing osteopenia among postmenopausal women. Our discussion explores a carefully crafted 48-week trial, analyzing its design, methodology, and compelling outcomes. Navigating the intersection of evidence-based medicine and holistic practices, we uncover a promising link between Shilajit and bone mineral density. This sparks a thoughtful conversation on its integration with modern osteoporosis treatments

We invite you, our listeners, to join us in this ongoing exploration. Share your thoughts, questions, and experiences on our social media platforms—DrJournalClub on Twitter, Facebook, and LinkedIn. Together, let's nurture a dialogue that celebrates the intersection of tradition and innovation, enriching our understanding of health and healing.

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Rosemary vs. Minoxidil: A Super Speedy Summary

Thu, 18 Apr 2024 10:00:00 -0400

Unlock the secrets of rosemary for hair loss with a comparison to minoxidil. Dr. Joshua Goldenberg presents a super speedy summary of a groundbreaking study comparing natural remedies to pharmaceuticals. Learn about efficacy, side effects, and innovative solutions for androgenic alopecia in this enlightening episode.

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Navigating Acupuncture for Endometriosis: A Critical Dive into Research and Patient Relief

Thu, 11 Apr 2024 10:00:00 -0400

Embark on a journey through integrative medicine with hosts Dr. Joshua Goldenberg and Dr. Adam Sadowski as they explore acupuncture's potential in treating endometriosis. Delve into recent research and meta-analysis, navigating acupuncture's efficacy and its impact on endometriosis-related pain. Join the enlightening conversation and connect with the hosts on social media at drjournalclub.com to drive evidence-based discussions forward.

https://pubmed.ncbi.nlm.nih.gov/38033648/
Giese N, Kwon KK, Armour M. Acupuncture for endometriosis: A systematic review and meta-analysis. Integr Med Res. 2023 Dec;12(4):101003. doi: 10.1016/j.imr.2023.101003. Epub 2023 Oct 28. PMID: 38033648; PMCID: PMC10682677.

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Investigating Ginger's Place in Migraine Therapy

Thu, 04 Apr 2024 10:00:00 -0400

In this episode, we explore the ongoing debate over ginger's potential to treat migraines. By dissecting a recent systematic review asserting ginger's efficacy, we meticulously examine research methods, including literature searches and study quality assessments. Through our analysis of the data supporting ginger's purported benefits for migraines, we uncover inconsistencies and overlooked errors. Ultimately, our discussion serves as a cautionary reminder of the intricate nature of medical research and the essential need for critical evaluation when considering potential remedies.

L. Chen and Z. Cai, The efficacy of ginger for the treatment of migraine: A meta-analysis of randomized controlled studies, American Journal of Emergency Medicine (2018), https://doi.org/10.1016/j.ajem.2020.11.030

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Medication for Obesity: A Swift Synopsis

Thu, 28 Mar 2024 10:00:00 -0400

Join us for a rapid-fire review of a groundbreaking study published in The Lancet by McMaster University. Explore the latest insights on weight loss treatments alongside esteemed scholars like Gordon Guyatt and Per Van Vick. With Dr. Goldenberg guiding us through the study's complexities, we quickly unpack findings from 143 trials involving nearly 50,000 participants. Witness the clash of heavyweight medications like the fentermine-topiramate combo, GLP-1 agonists, and naltrexone-bupropion duo, as they vie for supremacy in the battle against obesity. Don't miss out on this fast-paced discussion shedding light on the efficacy and safety of these interventions, offering clarity in the realm of weight loss treatments.

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Examining Ashwagandha's Stress-Busting Potential: A Systematic Review Dissection

Thu, 21 Mar 2024 10:00:00 -0400

In this edition of the Dr Journal Club podcast, hosts Josh and Adam delve into the captivating realm of Ashwagandha, an adaptogenic herb renowned for its stress-alleviating properties. They explore a systematic review and meta-analysis of randomized controlled trials investigating Ashwagandha's efficacy in managing anxiety and stress. Despite promising findings suggesting significant effects, the hosts meticulously scrutinize the study's methodology using the Amstar 2 checklist, identifying deficiencies such as the lack of a registered protocol and unclear reporting on funding sources. However, they underscore the importance of considering the results while acknowledging the low evidence level and study limitations. They advocate for critical evaluation of systematic reviews and encourage listeners to utilize tools like Amstar 2 to assess the quality of evidence in research studies.

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Is it True that Most Interventions are not Effective? A Super Speedy Review

Thu, 14 Mar 2024 13:00:00 -0400

Join us for a super speedy exploration of evidence-based integrative medicine with Dr. Joshua Goldenberg. In a landscape where only a fraction of medical practices have top-tier evidence, we scrutinize healthcare implications with Dr. Ian Edes from Stanford. Dr. Adam Sadowski joins to dissect findings, debating evidence standards and urging for rigorous research. Tune in for a stimulating discussion on the pressing need for high-quality evidence in medicine.

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Soothing the Mind with Electrical Waves Demystifying CES

Thu, 07 Mar 2024 10:00:00 -0500

Discover the lowdown on cranial electrical stimulation (CES), an FDA-approved method with promising results for anxiety, depression, insomnia, and pain.

Our exploration of cranial electrical stimulation (CES) highlights its promising potential for anxiety relief. While visual insights from randomized trials paint a positive picture, it's essential to approach these findings with scrutiny and an awareness of research complexities. As we navigate the evolving landscape of evidence-based integrative medicine, the conversation around CES continues, inviting ongoing exploration and discussion.

Chung FC, Sun CK, Chen Y, Cheng YS, Chung W, Tzang RF, Chiu HJ, Wang MY, Cheng YC, Hung KC. Efficacy of electrical cranial stimulation for treatment of psychiatric symptoms in patients with anxiety: A systematic review and meta-analysis. Front Psychiatry. 2023 Apr 6;14:1157473. doi: 10.3389/fpsyt.2023.1157473. PMID: 37091717; PMCID: PMC10115990.

Thank you for joining us on this insightful journey, and we look forward to continuing the conversation in our ongoing pursuit of knowledge and well-being within the realm of evidence-based integrative medicine.

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Which diets and foods work best for blood pressure?

Thu, 29 Feb 2024 10:00:00 -0500

Ever pondered how to navigate the vast sea of research on diets and blood pressure without losing your way? Join us as we uncover the layers of a recent Advances in Nutrition paper, presenting a valuable guide for healthcare professionals in the integrative medicine field.

Embarking on systematic reviews in dietary research often feels like embarking on a quest for the Holy Grail. In this installment, we express appreciation for the diligence required to scrutinize thousands of studies. Balancing admiration with a critical eye, we meticulously examine the utilization of tools such as AMSTAR and the Cochrane Risk-of-Bias to separate valuable insights from less substantial findings.

Aljuraiban GS, Gibson R, Chan DS, Van Horn L, Chan Q. The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies. Adv Nutr. 2024 Jan;15(1):100123. doi: 10.1016/j.advnut.2023.09.011. Epub 2023 Oct 1. PMID: 37783307; PMCID: PMC10831905.

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Diet Decoded: Navigating the Wahls Protocol and Unraveling Autoimmune Mysteries

Thu, 22 Feb 2024 10:00:00 -0500

Explore the role of diet in autoimmune diseases as we welcome back Heather's Wiki for an intriguing exploration of the Wahls protocol in managing Multiple Sclerosis (MS). Together, we analyze a a small MS diet study, offering a reality check on results versus discussion, separating scientific substance from noise. This episode sharpens your critical thinking skills, providing knowledge to navigate the complex realm of nutritional science.

Join us in addressing practical challenges in dietary intervention studies, such as small sample sizes and recruitment issues. In a lively discussion with Heather, we uncover biases in weight-list controls and adherence problems that can obscure research outcomes. This episode isn't just about effective strategies; it's a journey of discovery, highlighting the rigorous process ensuring scientific validity.

In this episode we will empower your critical thinking and understanding of research findings, while our candid analysis will guide you through interpreting these findings and understanding their clinical implications.

Lee JE, Titcomb TJ, Bisht B, Rubenstein LM, Louison R, Wahls TL. A Modified MCT-Based Ketogenic Diet Increases Plasma β-Hydroxybutyrate but Has Less Effect on Fatigue and Quality of Life in People with Multiple Sclerosis Compared to a Modified Paleolithic Diet: A Waitlist-Controlled, Randomized Pilot Study. J Am Coll Nutr. 2021 Jan;40(1):13-25. doi: 10.1080/07315724.2020.1734988. Epub 2020 Mar 26. PMID: 32213121.

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Zone 2 Revolution: Unleashing Athletic Performance with Dr. Greib

Thu, 15 Feb 2024 10:00:00 -0500

Join Dr. Joshua Goldenberg and Dr. Adam Sadowski with special guest Dr. Greib from the Sport Lab as they delve into the transformative world of Zone 2 training. Discover the profound impact of the low and slow approach on physiology, unravel the challenges in defining Zone 2, and acquire tools for smart training. Dr. Greib explores cellular benefits, discussing mitochondrial function, stress response, and exercise adaptation. From countering aging effects to scrutinizing fitness tracking devices, we navigate the realms of science and skepticism to guide you in redefining your training for peak fitness.

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Embarking on Holistic Wellness: Dr. Goldenberg and Dr. Davis Explore the World of Homeopathic Remedies

Thu, 08 Feb 2024 19:00:00 -0500

As we wrap up our exploration, we delve into the challenging task of assessing homeopathy's efficacy, considering not only scientific aspects but also clinical evidence and patient outcomes. The debate spans from the rigors of scientific reasoning to the inclusivity of evidence-based evaluation. Join doctors Goldenberg and Davis as they dive into the controversial topic of homeopathy.

Jacobs J, Jonas WB, Jiménez-Pérez M, Crothers D. Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials. Pediatr Infect Dis J. 2003 Mar;22(3):229-34. doi: 10.1097/01.inf.0000055096.25724.48. PMID: 12634583.

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Exercise for Hypertension, a Super Speedy Review

Thu, 01 Feb 2024 10:00:00 -0500

Discover the power of isometric exercises in combating hypertension, a prevalent issue among half of American adults. In this episode, we delve into a groundbreaking review from the British Journal of Sports Medicine, examining non-pharmacological interventions for managing blood pressure. Analyzing data from 270 trials with nearly 16,000 participants, we find that aerobic, resistance, and high-intensity interval training are effective, but isometric exercises, like wall sits, stand out by doubling the blood pressure-lowering effects. Join us as we explore these findings and their potential impact on future health recommendations.

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Challenging Assumptions in the Race to Diagnose

Thu, 25 Jan 2024 14:00:00 -0500

Embarking on a thought-provoking journey, our latest episode delves into the often-unseen impact of cognitive bias in the medical field. Drawing from Daniel Kahneman's "Thinking, Fast and Slow," we explore Type 1 and Type 2 thinking, uncovering how these mental shortcuts influence clinical decisions. We share stories, strategies, and insights on skepticism, emphasizing the value of revisiting initial diagnoses.

Navigating medical heuristics, we examine how biases like availability bias and base rate neglect shape our clinical landscape. We discuss balancing Occam's razor with comprehensive differential lists and the influence of diagnostic momentum. Confronting the challenge of 'doing nothing' in medicine, we highlight the art of balancing intervention with watchful waiting. Our reflections stress self-scrutiny and continuous learning in clinical decision-making, inviting the audience to deepen their understanding of evidence-based medicine and its psychological complexities.

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Dissecting the Efficacy of Probiotics Against Pediatric Strep Infections

Thu, 18 Jan 2024 10:00:00 -0500

Embark on an insightful exploration of pediatric health with hosts Josh and Adam. In this episode, we delve into the nuanced impact of probiotics on strep throat prevention. Take a guided tour through the intricate landscape of K12 Streptococcus salivarius research, acquiring a nuanced understanding of scientific papers. From elucidating the concept of 'lantibiotics' to dissecting the intricacies of clinical trials, we unravel the complexities of evidence-based integrative medicine. Navigate the challenges associated with industry-funded research and delve into proposed solutions for fostering transparency in the scientific landscape. Engage with us at josh@drjournalclub.com to contribute to the discourse and be a part of reshaping our approach to pediatric health.

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Navigating the Debate: Homeopathy's Effectiveness in Treating Depression

Thu, 11 Jan 2024 09:00:00 -0500

Explore the controversial realm of homeopathy with us as we delve into its role in evidence-based and integrative medicine, focusing on its claims in treating depression. Our meticulous review includes meta-analyses and randomized controlled trials, offering insights into real-world practice. The conversation intensifies with a study comparing homeopathy and Prozac in menopausal women battling depression, sparking a lively debate on research replication. We emphasize the need for strong evidence and eagerly await Dr. Davis's expertise in a future episode. Join our community on social media, share your reflections, and be part of the ongoing conversation. Whether skeptic or enthusiast, this episode is a must-listen for the inquisitive soul.

https://www.sciencedirect.com/science/article/pii/S1876382018304451
Petter Viksveen, Philippa Fibert, Clare Relton, Homeopathy in the treatment of depression: a systematic review, European Journal of Integrative Medicine, Volume 22, 2018, Pages 22-36.

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The Prime Study: A Super Speedy Review

Thu, 04 Jan 2024 10:00:00 -0500

Welcome to our new podcast! In this speedy episode, guided by Dr. Joshua Goldenberg, we explore the impact of pharmacogenetic testing on major depressive disorder treatment. The recently published Prime Study investigates whether these tests genuinely enhance remission rates, offering hope for those facing depression. Join us for a rapid journey through surprising outcomes, examining how genetic testing influences clinical decisions and its profound implications for patient care. Gain quick insights into depression treatment and the evolving role of genetic testing in personalized medicine. This is a brief but impactful discussion shaping our swift approach to mental health challenges.

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Probiotics For Mental Health

Thu, 28 Dec 2023 10:00:00 -0500

In this super speedy installment of the Dr. Journal Club podcast, we delve into the fascinating correlation between gastrointestinal well-being and mental health. Listen in as we take q quick look at the intricate ties between gut health and overall mental wellness, exploring the impact of probiotics on depression through health assessments and biomarkers.

Stay tuned for more captivating discussions on the Dr. Journal Club podcast, where we'll be sharing the most recent insights at the intersection of science and holistic well-being with you.

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The Unveiling of Homeopathy: Navigating Its Complexities, Part II

Thu, 21 Dec 2023 12:00:00 -0500

Step into the realm of homeopathy with us! In this episode, we navigate the intricacies of its efficacy, examining debates and studies with insights from expert Mark Davis. Using the Lind et al. meta-analysis as our guide, we scrutinize statistical challenges, shedding light on potential biases and the scientific scrutiny that studies endure.

Next, we delve into the controversial Lancet study comparing homeopathy to conventional medicine. Unpacking its rigorous methods and unique design, we reveal a methodological maelstrom questioning the quality of homeopathy research. Join our critical discussion on homeopathy evidence, where we dissect studies, invite listener and expert contributions, and share personal reflections. Together, we embark on an enlightening quest for truth, ensuring even the extraordinary claims withstand the rigors of scientific scrutiny.

https://www.sciencedirect.com/science/article/pii/S1876382018304451
Petter Viksveen, Philippa Fibert, Clare Relton, Homeopathy in the treatment of depression: a systematic review, European Journal of Integrative Medicine, Volume 22, 2018, Pages 22-36.

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The Unveiling of Homeopathy: Navigating Its Complexities

Wed, 13 Dec 2023 21:00:00 -0500

Welcome to our exploration of homeopathy. In this episode, we've uncovered its principles, delved into its history, and discussed why it remains popular despite limited scientific support. We've looked at different forms of homeopathy, explained dilution, and questioned whether it's just a placebo. Our discussion also touched on a meta-analysis, challenging our views on homeopathy and providing a nuanced perspective.

As we conclude our journey through this medical practice, we invite you to reflect on the complexities surrounding homeopathy. Join us in examining and delving into the diverse aspects of this field, fostering an open conversation about its role within the broader spectrum of healthcare.

https://www.sciencedirect.com/science/article/pii/S1876382018304451
Petter Viksveen, Philippa Fibert, Clare Relton, Homeopathy in the treatment of depression: a systematic review, European Journal of Integrative Medicine, Volume 22, 2018, Pages 22-36.

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Exploring the Microbiome: The Interplay of Food, Gut Health, and Inflammation

Wed, 06 Dec 2023 16:00:00 -0500

Embark on a journey through the intricate realm of the microbiome, uncovering the connection between your diet and gut health. Delve into the challenges of studying this complex system, exploring how dietary habits shape the trillions of microbes in your gut. From the effects of fiber and fermented foods to the importance of dietary variety, gain insights from recent studies. Explore the intricate interplay among diet, gut health, and inflammation, revealing surprising ways your microbiome is influenced by your choices and its potential impact on your overall well-being.

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The Statin Controversy: Reassessing Risks, Benefits, and the Involvement of Healthcare Professionals

Thu, 30 Nov 2023 12:00:00 -0500

Embark on a deep dive into the controversial world of statins, approaching it from the other side of the coin. Building on discussions from last week's podcast, we'll meticulously analyze a systematic review on the effectiveness of statins in preventing cardiovascular events, unraveling concepts like relative and absolute risk reduction. Understanding statin benefits involves recognizing baseline risk, enabling informed decisions with life-altering implications. Additionally, we'll explore a study shedding light on the differing perspectives on statin trade-offs between clinicians and patients, offering a unique viewpoint.

For further engagement, inquiries, and the exchange of insights, visit www.drjournalclub.com. Immerse yourself in evidence-based integrative medicine, where science converges with reality. Become a member at www.DrJournalClub.com and explore NANCEAC-approved Continuing Education Courses.

https://tools.acc.org/ascvd-risk-estimator-plus/#!/calculate/estimate/

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Investigating the Statin Controversy: Risks, Benefits and Role of Clinicians

Fri, 24 Nov 2023 12:00:00 -0500

Embark on a deep dive into the controversial world of statins. We'll analyze a systematic review on their effectiveness in preventing cardiovascular events, decoding concepts like relative and absolute risk reduction. Understanding statin benefits involves recognizing baseline risk and making informed decisions with life-altering implications. We'll also explore a study revealing differing perspectives on statin trade-offs between clinicians and patients.

Visit www.drjournalclub.com to engage, ask questions, and share suggestions. Explore evidence-based integrative medicine where science meets reality. Become a member at www.DrJournalClub.com, and discover NANCEAC-approved Continuing Education Courses.

Learn more and become a member at www.DrJournalClub.com

Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Ketamine for Depression: A Super Speedy Review

Thu, 16 Nov 2023 13:00:00 -0500

Tune in to this week's podcast episode for a super speedy exploration of a groundbreaking study on treating resistant depression with ketamine versus electroconvulsive therapy. Led by Dr. Joshua Goldenberg, we discuss key trial details, revealing raw facts and fascinating findings in evidence-based integrative medicine. Uncover unexpected suicide attempt rates, trial design nuances, and potential implications swiftly. Engage with us on social platforms and www.drjournalclub.com, where your learning journey continues.

This is a research review. It is not meant to diagnose or treat disease. For all things medical contact your healthcare professional. This is meant for educational purposes only. It reviews a new research paper you can find here.

Anand A, Mathew SJ, Sanacora G, Murrough JW, Goes FS, Altinay M, Aloysi AS, Asghar-Ali AA, Barnett BS, Chang LC, Collins KA, Costi S, Iqbal S, Jha MK, Krishnan K, Malone DA, Nikayin S, Nissen SE, Ostroff RB, Reti IM, Wilkinson ST, Wolski K, Hu B. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. N Engl J Med. 2023 Jun 22;388(25):2315-2325. doi: 10.1056/NEJMoa2302399. Epub 2023 May 24. PMID: 37224232.

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MIND Diet Trial: A Super Speedy Review

Thu, 09 Nov 2023 15:00:00 -0500

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Examining the Efficacy of Pain Reprocessing Therapy in Chronic Back Pain - Part 2

Wed, 01 Nov 2023 21:00:00 -0400

Welcome to the second part of our captivating two-part podcast series. In this episode, we draw our exploration of the groundbreaking realm of pain reprocessing therapy to a close and its potential to be a life-changing solution for those enduring chronic back pain.

As we delve deep into the study, we take you on a fascinating journey through the human brain's reaction to pain, utilizing MRI scans to compare the responses of those undergoing therapy with those who received placebos. This objective data provides solid evidence of the therapy's effectiveness.

We wholeheartedly invite you to engage with us, sharing your thoughts, questions, and reflections on the topics we've delved into. Your input is invaluable, so please reach out, share your insights, and embark on this enlightening journey of discovery alongside us.

Ashar YK, Gordon A, Schubiner H, Uipi C, Knight K, Anderson Z, Carlisle J, Polisky L, Geuter S, Flood TF, Kragel PA, Dimidjian S, Lumley MA, Wager TD. Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial. JAMA Psychiatry. 2022 Jan 1;79(1):13-23. doi: 10.1001/jamapsychiatry.2021.2669. PMID: 34586357; PMCID: PMC8482298.

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Examining the Efficacy of Pain Reprocessing Therapy in Chronic Back Pain - Part 1

Mon, 23 Oct 2023 19:00:00 -0400

In this unique two part podcast series, we'll start with Josh's firsthand account of successfully completing his inaugural triathlon, we will then shift our focus where we'll guide you through the intricate world of a randomized control trial of PRT, from the meticulous process of participant selection to the intricacies of statistical analysis. Plus, we'll delve into the ethical considerations, power analysis, and the three arms of the trial.

Stay tuned for Part 2, where we'll continue to uncover the mysteries of the randomized control trial of PRT. It's a rollercoaster of knowledge, laughter, and experiences - so buckle up and join us on this enlightening ride!

Ashar YK, Gordon A, Schubiner H, Uipi C, Knight K, Anderson Z, Carlisle J, Polisky L, Geuter S, Flood TF, Kragel PA, Dimidjian S, Lumley MA, Wager TD. Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial. JAMA Psychiatry. 2022 Jan 1;79(1):13-23. doi: 10.1001/jamapsychiatry.2021.2669. PMID: 34586357; PMCID: PMC8482298.

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Exploring the Depths: Chronic Pain Management and the Impact of Medical Cannabis

Thu, 19 Oct 2023 11:00:00 -0400

This episode of the Dr. Journal Club podcast offers an enlightening exploration into the realm of chronic pain and the potential role of medical cannabis in its management. In our latest podcast episode we explore the impact of medical cannabis on chronic pain management. Today we turn the spotlight onto a really excellent clinical practice guideline from the BMJ from a really stellar research group.

Also, tune in for some noteworthy nuggets from our EBM Boot Camp, designed to empower clinicians in critically evaluating literatureJoin us in this riveting episode that promises to challenge your perspective on chronic pain management and the potential role of medical cannabis. Remember to join the conversation and share your thoughts with us on our social media channels at Dr Journal Club!

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Bridging the Gap: Integrity, Ethics, and Transparency in Integrative Medicine Research

Thu, 05 Oct 2023 12:00:00 -0400

In our latest podcast episode, we extract valuable insights from a recent Council for Responsible Nutrition conference. We tackle the hot-button issue of industry sponsorship and its potential sway on research trials. How can we ensure transparency, communication, and uphold the independence of safety boards? Through an engaging conversation, we address these essential questions and underscore the need for collaboration between industry and academic centers to maintain the integrity of research methods.

We stress the importance of a radically transparent approach and a priori registration of methods to uphold the highest ethical standards. We also explore the intricacies of FDA regulation within the supplement industry, the necessity for continuous learning, and the value of challenging one's beliefs. So, tune in to our engrossing conversation and discover how you can stay ahead in the fast-paced world of integrative medicine research.

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Diet for Generalized Anxiety & Evidence-Based Training Among Canadian Naturopaths

Thu, 28 Sep 2023 13:00:00 -0400

Join us for a great interview with Dr. Monique Aucoin. She discusses her past work on designing evidence-based medicine training for naturopathic doctors in Canada as well as her current trial on using a specific diet to improve anxiety symptoms in those with GAD.

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Leach MJ, Aucoin M, Cooley K. Canadian Naturopathic Doctor Engagement, Preparedness, and Perceptions of Evidence-Based Practice: A National Cross-Sectional Study. J Integr Complement Med. 2022 Dec;28(12):955-964. doi: 10.1089/jicm.2022.0637. Epub 2022 Sep 9. PMID: 36083287.

Monique Aucoin, Laura LaChance, Inge van der Wurff et al. Dietary counselling plus omega-3 supplementation in the treatment of generalized anxiety disorder: Protocol for a randomized wait-list controlled pilot trial (the “EASe-GAD Trial”), 28 February 2023, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-2543723/v1]

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Curcumin vs. Proton Pump Inhibitors for Functional Dyspepsia

Thu, 21 Sep 2023 12:00:00 -0400

Join us for a discussion of a great, well-reported, and clinically relevant study. Is Curcumin essentially equivalent to omeprazole for functional dyspepsia?

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Kongkam P, Khongkha W, Lopimpisuth C, Chumsri C, Kosarussawadee P, Phutrakool P, Khamsai S, Sawanyawisuth K, Sura T, Phisalprapa P, Buamahakul T, Siwamogsatham S, Angsusing J, Poonniam P, Wanaratna K, Teerachaisakul M, Pongpirul K. Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial. BMJ Evid Based Med. 2023 Sep 11:bmjebm-2022-112231. doi: 10.1136/bmjebm-2022-112231. Epub ahead of print. PMID: 37696679

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What Works For Osteoporosis? Results from the new network meta-analysis

Thu, 14 Sep 2023 10:00:00 -0400

Join us for a super speedy summary of the new network meta-analysis exploring the efficacy and safety of different medications for osteoporosis.

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Earn CEU and take one of our courses, like our Critical Evaluation of the Literature Bootcamp: https://drjournalclub.com/critical-evaluation-bootcamp/

Händel MN, Cardoso I, von Bülow C, Rohde JF, Ussing A, Nielsen SM, Christensen R, Body JJ, Brandi ML, Diez-Perez A, Hadji P, Javaid MK, Lems WF, Nogues X, Roux C, Minisola S, Kurth A, Thomas T, Prieto-Alhambra D, Ferrari SL, Langdahl B, Abrahamsen B. Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials. BMJ. 2023 May 2;381:e068033. doi: 10.1136/bmj-2021-068033. PMID: 37130601; PMCID: PMC10152340.

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So Is Testosterone Safe Now? Super Speedy Summary

Thu, 07 Sep 2023 09:00:00 -0400

This is a research review. It is not meant to diagnose or treat disease. For all things medical contact your healthcare professional. This video is meant for educational purposes only. It reviews a new research paper you can find here.

Learn more and become a member on https://drjournalclub.com/

Learn more and become a member at www.DrJournalClub.com

Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Slitting our own throats? Vitalism & Evidence-Based Chiropractic/Naturopathic Medicine.

Thu, 31 Aug 2023 14:00:00 -0400

Join us for a fascinating conversation with Dr. Martin Gurvey, DC. We discuss the philosophy of evidence-based medicine, vitalism, and how the two interact and/or bifurcate within our professions.

Become a member and learn more at https://drjournalclub.com/

Logan AC, Goldenberg JZ, Guiltinan J, Seely D, Katz DL. North American naturopathic medicine in the 21st century: Time for a seventh guiding principle - Scientia Critica. Explore (NY). 2018 Sep;14(5):367-372. doi: 10.1016/j.explore.2018.03.009. Epub 2018 Aug 2. PMID: 30217641.

Use of Complementary and Integrative Approaches: Avoiding Irrational Dichotomies
https://www.nwrpca.org/news/616940/Use-of-Complementary-and-Integrative-Approaches-Avoiding-Irrational-Dichotomies.htm

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Do Proton Pump Inhibitors Cause Dementia? A Birthday Pod!

Thu, 24 Aug 2023 13:00:00 -0400

Happy birthday Adam!

Join us for this special birthday Pod where we discuss a fascinating new meta-analysis on the association of PPIs and Dementia.

Learn about the study's results, methods, a rabbit hole about prediction intervals, and Adam's Tupperware approach to confidence intervals.

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PPIs and Barrett's Continuing Education Course: https://drjournalclub.com/continuing-education/

Ahn N, Nolde M, Krause E, Güntner F, Günter A, Tauscher M, Gerlach R, Meisinger C, Linseisen J, Baumeister SE, Rückert-Eheberg IM. Do proton pump inhibitors increase the risk of dementia? A systematic review, meta-analysis and bias analysis. Br J Clin Pharmacol. 2023 Feb;89(2):602-616. doi: 10.1111/bcp.15583. Epub 2022 Nov 23. PMID: 36331350.

Kumar R, Kumar A, Nordberg A, Långström B, Darreh-Shori T. Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia. Alzheimers Dement. 2020 Jul;16(7):1031-1042. doi: 10.1002/alz.12113. Epub 2020 May 8. PMID: 32383816.

Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. BMJ. 2011 Feb 10;342:d549. doi: 10.1136/bmj.d549. PMID: 21310794.

IntHout J, Ioannidis JP, Rovers MM, Goeman JJ. Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open. 2016 Jul 12;6(7):e010247. doi: 10.1136/bmjopen-2015-010247. PMID: 27406637; PMCID: PMC4947751.

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Glutamine for IBS - plus kindergarten angst and moving across the country

Thu, 17 Aug 2023 13:00:00 -0400

Join us as we discuss a randomized controlled trial on the use of glutamine for post-infectious IBS. Very clinically useful information! We also discuss Adam's move and Josh's struggles with the start of the kiddos' school year.

Learn more, subscribe, and browse our continuing education courses on https://drjournalclub.com/

Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019 Jun;68(6):996-1002. doi: 10.1136/gutjnl-2017-315136. Epub 2018 Aug 14. PMID: 30108163; PMCID: PMC9549483.

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Meds Shaming & The MIND Trial - A Diet to Prevent Dementia?

Thu, 10 Aug 2023 14:00:00 -0400

Join us as we discuss med shaming as well as diving into the recent results of the MIND trial, which looked at a specific dietary intervention in people at risk for developing dementia.

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Barnes LL, Dhana K, Liu X, Carey VJ, Ventrelle J, Johnson K, Hollings CS, Bishop L, Laranjo N, Stubbs BJ, Reilly X, Agarwal P, Zhang S, Grodstein F, Tangney CC, Holland TM, Aggarwal NT, Arfanakis K, Morris MC, Sacks FM. Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons. N Engl J Med. 2023 Jul 18. doi: 10.1056/NEJMoa2302368. Epub ahead of print. PMID: 37466280.

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Maintenance vs. Symptom-Driven Chiropractic Care

Fri, 04 Aug 2023 04:00:00 -0400

Join us for this super speedy summary of the Nordic Maintenance Care study looking at the effectiveness and cost of a symptom-driven versus a maintenance approach to chiropractic care.

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Check out our EBM Bootcamp Course

Eklund A, Jensen I, Lohela-Karlsson M, Hagberg J, Leboeuf-Yde C, Kongsted A, Bodin L, Axén I. The Nordic Maintenance Care program: Effectiveness of chiropractic maintenance care versus symptom-guided treatment for recurrent and persistent low back pain-A pragmatic randomized controlled trial. PLoS One. 2018 Sep 12;13(9):e0203029. doi: 10.1371/journal.pone.0203029. PMID: 30208070; PMCID: PMC6135505.

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"Now their stomachs are paralyzed" - Really?

Thu, 27 Jul 2023 11:00:00 -0400

Join us on the pod, where we discuss a recent CNN article suggesting long-standing negative side effects with semaglutide. We discuss this, a high-quality network meta-analysis on this and other weight loss drugs for diabetics, and what being an evidence-based provider means.

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Critical Evaluation of the Medical Literature Bootcamp

The CNN article

The BMJ Study

The commentary on staying curious as a clinician.

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So Is Testosterone Safe Now? We review the just released results of the TRAVERSE Study

Thu, 20 Jul 2023 16:00:00 -0400

Josh and Adam discuss the new NEJM study on the use of Testosterone in men at high risk for cardiovascular events.

Learn more on www.DrJournalClub.com

Check out our Critical Evaluation of the Literature Bootcamp Course.

Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, Basaria S, Boden WE, Cunningham GR, Granger CB, Khera M, Thompson IM Jr, Wang Q, Wolski K, Davey D, Kalahasti V, Khan N, Miller MG, Snabes MC, Chan A, Dubcenco E, Li X, Yi T, Huang B, Pencina KM, Travison TG, Nissen SE; TRAVERSE Study Investigators. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023 Jul 13;389(2):107-117. doi: 10.1056/NEJMoa2215025. Epub 2023 Jun 16. PMID: 37326322.

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Treatments for Low Back Pain

Thu, 13 Jul 2023 07:00:00 -0400

Join us for this super speedy review of a recent study on the benefits and harms of treatments for chronic nonspecific low back pain without radiculopathy.

We review the below study: https://pubmed.ncbi.nlm.nih.gov/36400393/

Feise RJ, Mathieson S, Kessler RS, Witenko C, Zaina F, Brown BT. Benefits and harms of treatments for chronic nonspecific low back pain without radiculopathy: systematic review and meta-analysis. Spine J. 2023 May;23(5):629-641. doi: 10.1016/j.spinee.2022.11.003. Epub 2022 Nov 17. PMID: 36400393.

Learn more on www.DrJournalClub.com

Take our Evidence-Based Medicine Bootcamp: https://drjournalclub.com/critical-evaluation-bootcamp/

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Are laxatives associated with dementia? Listener requested article review

Thu, 06 Jul 2023 14:00:00 -0400

Join us as we dissect a study on the association between laxative use and dementia.

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More info:
https://pubmed.ncbi.nlm.nih.gov/36870957/

https://drjournalclub.com/propensity-scores/

Feng J, Zheng N, Fan X, Li S, Jiang Y, Yi X, Yang H. Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching. BMC Geriatr. 2023 Mar 4;23(1):122. doi: 10.1186/s12877-023-03854-w. PMID: 36870957; PMCID: PMC9985868.

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Is AI going to change the world? The future of Evidence Synthesis, Systematic Reviews, and Medicine

Thu, 18 May 2023 11:00:00 -0400

Join us for a fascinating conversation with Dr. Riaz Qureshi. We talk about his latest commentary paper on Chat GPT and Systematic Reviews and have a broader conversation about how AI and Machine Learning is changing medicine and evidence synthesis in general.

Qureshi, R., Shaughnessy, D., Gill, K.A.R. et al. Are ChatGPT and large language models “the answer” to bringing us closer to systematic review automation?. Syst Rev 12, 72 (2023). https://doi.org/10.1186/s13643-023-02243-z

Cacciamani, G.E., Chu, T.N., Sanford, D.I. et al. PRISMA AI reporting guidelines for systematic reviews and meta-analyses on AI in healthcare. Nat Med 29, 14–15 (2023). https://doi.org/10.1038/s41591-022-02139-w

International Collaboration for the Automation of Systematic Reviews

https://picoportal.org/

https://drjournalclub.com/critical-evaluation-bootcamp/

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It's up to you to provide an evidence base!

Thu, 04 May 2023 11:00:00 -0400

Join us as we meet with Ryan Wexler, a National University of Natural Medicine naturopathic medicine student who is about to start his post-doctoral research at the Cleveland Clinic.

We talk about:

How we all got our 'fire in the belly' for research
It's up to you to provide an evidence base
Setting yourself up for a research career as a medical student
Bubbling up versus trickling down
Cold calls (dozens of them)
Take on extra work
The 'iron curtain' of research

Check out our Critical Evaluation of the Medical Literature Bootcamp.

Check out some of Ryan and Adam's work:

Wexler RS, Fox DJ, Edmond H, Lemau J, ZuZero D, Bollen M, Montenegro D, Parikshak A, Thompson AR, Carlson NL, Carlson HL, Wentz AE, Bradley R, Hanes DA, Zwickey H, Pickworth CK. Protocol for mindfulness-oriented recovery enhancement (MORE) in the management of lumbosacral radiculopathy/radiculitis symptoms: A randomized controlled trial. Contemp Clin Trials Commun. 2022 Jul 3;28:100962. doi: 10.1016/j.conctc.2022.100962. PMID: 35812821; PMCID: PMC9260614.

Sadowski A, Dunlap C, Lacombe A, Hanes D. Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Clin Transl Gastroenterol. 2020 Dec 18;12(1):e00275. doi: 10.14309/ctg.0000000000000275. PMID: 33346998; PMCID: PMC7752679.

Follow Ryan:
LinkedIn: https://www.linkedin.com/in/ryan-wexler24
ResearchGate: https://www.researchgate.net/profile/Ryan-Wexler-2

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How do you get research that matters? The idea of a definitive study is absurd!

Thu, 27 Apr 2023 11:00:00 -0400

Josh and Adam talk about a recent paper on implementing evidence. We discuss:

How do you apply research to clinic?
Why do we even care about mechanism of action studies?
Is there such a thing as a definitive study?
Evidence is organic.

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

PEA for Diabetic Neuropathy

Thu, 20 Apr 2023 09:00:00 -0400

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Vaccine Hesitancy, Epistemic Trust, and "The Guardians of Truth"

Thu, 13 Apr 2023 11:00:00 -0400

Join us for a wonderful conversation with philosopher of science Dr. Maya Goldenberg, PhD (www.mayagoldenberg.ca). We discuss her book Vaccine Hesitancy and how this topic applies to covid, childhood vaccinations, and more.

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The Cochrane Mask Maelstrom - Josh and Adam's Take

Thu, 23 Mar 2023 12:00:00 -0400

Join us as we discuss the highly debated Cochrane Review on interventions to promote using masks to prevent the spread of COVID19.

Jefferson T, Dooley L, Ferroni E, Al-Ansary LA, van Driel ML, Bawazeer GA, Jones MA, Hoffmann TC, Clark J, Beller EM, Glasziou PP, Conly JM. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev. 2023 Jan 30;1(1):CD006207. doi: 10.1002/14651858.CD006207.pub6. PMID: 36715243; PMCID: PMC9885521.

https://www.cochrane.org/news/statement-physical-interventions-interrupt-or-reduce-spread-respiratory-viruses-review

https://www.ndprimarycare.org/

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Hard Outcomes for What's next after Metformin? The GRADE Diabetes Trial

Thu, 16 Mar 2023 10:00:00 -0400

Join us as we briefly review the findings from the GRADE Diabetes trial. Learn more in our Basic and In Depth videos on this study on www.DrJournalClub.com.

GRADE Study Research Group; Nathan DM, Lachin JM, Bebu I, Burch HB, Buse JB, Cherrington AL, Fortmann SP, Green JB, Kahn SE, Kirkman MS, Krause-Steinrauf H, Larkin ME, Phillips LS, Pop-Busui R, Steffes M, Tiktin M, Tripputi M, Wexler DJ, Younes N. Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. N Engl J Med. 2022 Sep 22;387(12):1075-1088. doi: 10.1056/NEJMoa2200436. PMID: 36129997; PMCID: PMC9832916.

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Guidelines Are Like Ikea Furniture. The New Time Needed to Treat Idea.

Thu, 09 Mar 2023 12:00:00 -0500

Join us as we discuss a fascinating new paper from Minna Johansson, Gordon Guyatt, and Victor Montori. Do we need to account for clinician time in developing guidelines? There is something about addressing time that forces prioritization. Did this simple idea just change everything?

https://pubmed.ncbi.nlm.nih.gov/36596571/
Johansson M, Guyatt G, Montori V. Guidelines should consider clinicians' time needed to treat. BMJ. 2023 Jan 3;380:e072953. doi: 10.1136/bmj-2022-072953. PMID: 36596571.

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PIE 2023 with Gordon-FREAKIN-Guyatt and "Quick get me an EBM Consult STAT"

Thu, 02 Mar 2023 12:00:00 -0500

Join us for a great discussion about the upcoming PIE conference (Process of Integrating Evidence for Complementary and Integrative Health). We welcome educators Dr. Tony Tibbles and Dr. Craig Jacobs from the Canadian Memorial Chiropractic College and discuss the conference but also novel new ways to bring Evidence-Based Practice to clinic and culture change within Chiropractic.

Links:
Register for the PIE conference here: https://www.thepieconference.org/
Previous Pod discussion with Heather Zwickey, PhD on the R25 and culture change within naturopathic medicine
Josh's research on culture change within the naturopathic community

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Covid Vaccines, Snow Storms, and Absolute vs. Relative Risk - Listener Questions

Thu, 23 Feb 2023 17:00:00 -0500

Join us as we discuss a listener question regarding reporting absolute versus relative risk in covid vaccine studies. Outcome reporting bias? Was it misleading?

Episode Links
Brown RB. Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials. Medicina (Kaunas). 2021 Feb 26;57(3):199. doi: 10.3390/medicina57030199. PMID: 33652582; PMCID: PMC7996517.
Dr. Journal Club videos on ARR vs. RR: https://drjournalclub.com/ebm-skills/

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

What do you add after Metformin? The GRADE Diabetes Trial

Thu, 16 Feb 2023 10:00:00 -0500

Join us as we briefly review the findings from the GRADE Diabetes trial. Learn more in our Basic and In Depth videos on this study on www.DrJournalClub.com.

GRADE Study Research Group; Nathan DM, Lachin JM, Balasubramanyam A, Burch HB, Buse JB, Butera NM, Cohen RM, Crandall JP, Kahn SE, Krause-Steinrauf H, Larkin ME, Rasouli N, Tiktin M, Wexler DJ, Younes N. Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes. N Engl J Med. 2022 Sep 22;387(12):1063-1074. doi: 10.1056/NEJMoa2200433. PMID: 36129996; PMCID: PMC9829320.

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

A Hallmark Movie?! The Early Days of EBM and Integrative Medicine

Thu, 09 Feb 2023 14:00:00 -0500

Join us for a great conversation with our guest Dr. Heather Zwickey, PhD. We talk about the early days of EBM in Integrative Medicine. From, "Why are you trying to destroy our medicine?!" to EBM champions and the thorough integration of the EBM 'way of thinking' into training institutions.

Check out more on www.DrJournalClub.com and become a member.
Learn more about Dr. Zwickey here: www.heatherzwickey.com
Some of Dr. Zwickey's papers on the topics we discussed.

Allen, E S., Connelly, E.N., Morris, C.D., Elmer, P.J., and H. Zwickey. A Train the Trainer Model for Integrating Evidence-Based Medicine into a Complementary and Alternative Medicine Training Program. Explore (NY). 2011 Mar-Apr;7(2):88-93.
Connelly, E. N., Elmer, P. J., Morris, C. D., and H. Zwickey. The Vanguard Faculty Program: Research Training for Complementary and Alternative Medicine Faculty. Journal of Alternative and Complementary Medicine. 2010 Oct;16(10):1117-23.
Senders, A., Erlandsen, E. and H. Zwickey. The Importance of Research Literacy. The Natural Medicine Journal. 2014 Aug: 6(8):
Zwickey, H., Schiffke, H., Fleishman, S., Haas, M., Cruser, D., LeFebvre, R., Sullivan, B., Taylor, B. and B. Gaster. Teaching Evidence-Based Medicine at Complementary and Alternative Medicine Institutions. Strategies, Competencies and Evaluation. Journal of Alternative and Complementary Medicine. 2014 Dec;20(12):925-31. PMID: 25380144

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Does EBM even work for Integrative Medicine? Listener Questions

Thu, 02 Feb 2023 11:00:00 -0500

Join us for a fascinating discussion on the utility of the EBM model in an Integrative Medicine environment. Does it work? Does the application of trials need to be tweaked? How about the study design?

Links to topics discussed:
Sytematic Review of Whole Systems Naturopathic Medicine
Our Podcast on the Lexapro vs. Meditation study
Our Podcast on Medical Nihilism with Dr. Brignall

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Medical nihilism vs. medical denialism

Sat, 28 Jan 2023 03:00:00 -0500

Join our conversation about Medical Nihilism with Dr. Matt Brignall. We discuss Jacob Stegenga's book, how it plays out in a pandemic environment, and more.

Medical Nihilism by Jacob Stegenga

Dr. Matt Brignall

@drbrignall on Twitter

DrJournalClub videos on weight loss medications

Victor Montori

Evidence-Based Medicine has been Hijacked

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Are we teaching EBM all wrong?

Sat, 21 Jan 2023 06:00:00 -0500

Join us as we discuss how to best teach evidence-based medicine. Common pitfalls and evidence nihilism. Learn more on https://drjournalclub.com/

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.

Escitalopram (Lexapro) vs. Meditation

Sat, 21 Jan 2023 06:00:00 -0500

Enjoy our super speedy summary of this fascinating study. Check out www.DrJournalClub.com to watch videos of this as well as more detailed and in-depth versions with analysis, take-homes, and even article walk-throughs where we show you what to look for when taking apart a research article. Oh, and we have approved continuing education courses as well! Read the research article here.

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Check out our complete offerings of NANCEAC-approved Continuing Education Courses.