If you (recklessly) leave your urban office for lunch, you are told to yank your hat down low. If you (again, recklessly) let your kids dash into the backyard, you are told to slather them in sunscreen—or learn to live with the guilt.

And yes, sun avoidance undoubtedly prevents some skin cancers, including the deadliest type, melanoma

But a recent study suggests lack of sunlight contributes to hundreds of thousands of deaths every year in the United States alone,  This is orders of magnitude more than the estimated 8400 annual deaths from melanoma.

In this episode, we discuss evidence linking sun avoidance to

• almost a million annual deaths in the US and Europe alone, four times more deaths than caused by all the shooting wars, globally, each year.
• increased risk of breast, pancreatic, colon, and lung cancers, as well as heart disease, high blood pressure, and stroke
• and, perhaps most surprisingly, to INCREASED risk of death in those already diagnosed with sun-induced melanoma.

Yes, you read that right; some melanoma deaths may be related to too little sunlight.  (But do understand that this is complex--sunlight DOES cause melanoma. Well, some melanomas are not caused by sun exposure, and we discuss those....)

Lack of sun exposure is not fixed by taking vitamin D, unfortunately. We explore the evidence that supplementing with vitamin D pills fails to remedy these terrible conditions, and what a thoughtful person can do instead, while staying safe.

We hope you enjoy this episode, and that it helps you enjoy the sun again--thoughtfully, of course. 

References and further reading:

1.   Sunlight: Time for a Rethink?
2. Benefits of oral Polypodium leucotomas extract in MM high risk patients (This is an ingredient in Life Extension’s Shade Factor, mentioned in this episode by Dr. Gordon).
3.  Uses of Polypodium leucotomos Extract in Oncodermatology  Calzari et al
4. Insufficient Sun Exposure Has Become a Real Public Health Problem. Alfredsson L, Armstrong BK, Butterfield DA, et al. International Journal of Environmental Research and Public Health. 2020;17(14):E5014. doi:10.3390/ijerph17145014.
5. Prospective Study of Ultraviolet Radiation Exposure and Risk of Cancer in the United States. Lin SW, Wheeler DC, Park Y, et al. International Journal of Cancer. 2012;131(6):E1015-23. doi:10.1002/ijc.27619.
6. An Estimate of Premature Cancer Mortality in the U.S. Due to Inadequate Doses of Solar Ultraviolet-B Radiation. Grant WB. Cancer. 2002;94(6):1867-75. doi:10.1002/cncr.10427.
7. Solar Ultraviolet-B Exposure and Cancer Incidence and Mortality in the United States, 1993-2002. Boscoe FP, Schymura MJ. BMC Cancer. 2006;6:264. doi:10.1186/1471-2407-6-264.
8. Ecological Studies of the UVB-vitamin D-Cancer Hypothesis. Grant WB. Anticancer Research. 2012;32(1):223-36.
9. Sunlight Exposure in Association With Risk of Lymphoid Malignancy: A Meta-Analysis of Observational Studies. Kim HB, Kim JH. Cancer Causes & Control : CCC. 2021;32(5):441-457. doi:10.1007/s10552-021-01404-6.
10. Adulthood Residential Ultraviolet Radiation, Sun Sensitivity, Dietary Vitamin D, and Risk of Lymphoid Malignancies in the California Teachers Study. Chang ET, Canchola AJ, Cockburn M, et al. Blood. 2011;118(6):1591-9. doi:10.1182/blood-2011-02-336065.
11. Is Prevention of Cancer by Sun Exposure More Than Just the Effect of Vitamin D? A Systematic Review of Epidemiological Studies. van der Rhee H, Coebergh JW, de Vries E. European Journal of Cancer (Oxford, England : 1990). 2013;49(6):1422-36. doi:10.1016/j.ejca.2012.11.001.
12. An Ecologic Study of Cancer Mortality Rates in Spain With Respect to Indices of Solar UVB Irradiance and Smoking. Grant WB. International Journal of Cancer. 2007;120(5):1123-8. doi:10.1002/ijc.22386.
13. Does Sunlight Prevent Cancer? A Systematic Review. van der Rhee HJ, de Vries E, Coebergh JW. European Journal of Cancer (Oxford, England : 1990). 2006;42(14):2222-32. doi:10.1016/j.ejca.2006.02.024.
14. Heliovaccination: Solar mediated immunity against cancer. Uzoigwe CE. Experimental Dermatology. 2020;29(5):477-480. doi:10.1111/exd.14087.
15. Beneficial Health Effects of Ultraviolet Radiation: Expert Review and Conference Report. Riedmann U, Dibben C, de Gruijl FR, et al. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. 2025;24(6):867-893. doi:10.1007/s43630-025-00743-6.
16. A Blueprint for the Primary Prevention of Cancer: Targeting Established, Modifiable Risk Factors. Gapstur SM, Drope JM, Jacobs EJ, et al. CA: A Cancer Journal for Clinicians. 2018;68(6):446-470. doi:10.3322/caac.21496.
17. Proportion and Number of Cancer Cases and Deaths Attributable to Potentially Modifiable Risk Factors in the United States, 2019. Islami F, Marlow EC, Thomson B, et al. CA: A Cancer Journal for Clinicians. 2024 Sep-Oct;74(5):405-432. doi:10.3322/caac.21858.
18. Cutaneous Melanoma. Joshi UM, Kashani-Sabet M, Kirkwood JM. JAMA. 2025;334(23):2113-2125. doi:10.1001/jama.2025.13074.
19. Sunlight, Vitamin D and the Prevention of Cancer: A Systematic Review of Epidemiological Studies. van der Rhee H, Coebergh JW, de Vries E. European Journal of Cancer Prevention : The Official Journal of the European Cancer Prevention Organisation (ECP). 2009;18(6):458-75. doi:10.1097/CEJ.0b013e32832f9bb1.
20. Lessons Learned From Paleolithic Models and Evolution for Human Health: A Snap Shot on Beneficial Effects and Risks of Solar Radiation. Reichrath J. Advances in Experimental Medicine and Biology. 2020;1268:3-15. doi:10.1007/978-3-030-46227-7_1.
21. PS-Vitamin D. American Academy of Dermatology (2022).
22. American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity. Kushi LH, Byers T, Doyle C, et al. CA: A Cancer Journal for Clinicians. 2006;56(5):254-81; quiz 313-4. doi:10.3322/canjclin.56.5.254.
23. Vitamin D, Sunlight and Cancer Connection. Holick MF. Anti-Cancer Agents in Medicinal Chemistry. 2013;13(1):70-82.
24. Survivorship. National Comprehensive Cancer Network. Updated 2026-04-08.
25. Keratinocyte Carcinoma. Wehner MR. JAMA. 2025;:2840731. doi:10.1001/jama.2025.18749.
26. Public Awareness and Behaviour in Great Britain in the Context of Sunlight Exposure and Vitamin D: Results From the First Large-Scale and Representative Survey. Burchell K, Rhodes LE, Webb AR. International Journal of Environmental Research and Public Health. 2020;17(18):E6924. doi:10.3390/ijerph17186924.
27. Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force Recommendation Statement. US Preventive Services Task Force, Grossman DC, Curry SJ, et al. JAMA. 2018;319(11):1134-1142. doi:10.1001/jama.2018.1623.
28. Lifetime Sunburn Trajectories and Associated Risks of Cutaneous Melanoma and Squamous Cell Carcinoma Among a Cohort of Norwegian Women. Lergenmuller S, Rueegg CS, Perrier F, et al. JAMA Dermatology. 2022;158(12):1367-1377. doi:10.1001/jamadermatol.2022.4053.
29. Cancer Prevention and Early Detection Facts & Figures. Rick Alteri, Deana Baptiste, Emily Butler Bell, et al. American Cancer Society (2025).
30.  
31. Skin Cancer, Irradia

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Kill as many cancer cells as possible, as quickly as possible.

In some cases, that may be exactly the wrong approach.

In this episode, Dr. Dawn Lemanne and Dr. Deborah Gordon explore a surprising idea emerging from evolutionary biology, ecology, and mathematical oncology: in some metastatic cancers, aggressive treatment may unintentionally accelerate the growth of treatment-resistant cancer cells.

Using examples ranging from DDT-resistant boll weevils to metastatic prostate cancer, they discuss:

• Why cancer treatments stop working in advanced cancers

• How cancer cells evolve resistance

• How treatment-sensitive cancer cells actually help control more dangerous treatment-resistant cancer cells 

• The concept of "competitive release" and how treatment can unintentionally remove the competition that restrains resistant cancer cells

• How new blood tests called circulating tumor DNA (ctDNA) allow physicians to monitor cancer in real time

• The emerging field of adaptive cancer therapy, in which treatment intensity is adjusted in response to the cancer's evolutionary behavior

• The research suggesting that overtreatment can sometimes shorten, rather than prolong, cancer control

Along the way, they explore groundbreaking work mathematical oncologists and cancer evolution researchers, and discuss a radically different way of thinking about advanced cancer—not simply as an enemy to destroy, but as an evolving ecosystem whose behavior may be influenced and, in some cases, steered.

This conversation applies to advanced metastatic cancers that cannot be cured with current treatments. It does not challenge the importance of aggressive treatment for cancers that remain potentially curable.

The question explored in this episode is simple:

Can killing more cancer cells sometimes make cancer worse?

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

From that starting point, we explore several unexpected ideas:

•  Estrogen alone may reduce breast cancer risk in certain groups 
•  Not all “progesterone” is the same—synthetic versions can behave very differently 
•  The way a hormone is delivered (pill vs patch vs topical) can significantly change its effects 
•  Hormones are often prescribed without measuring levels—unlike almost every other hormone in medicine 
•  Many key hormones, including estrogen and testosterone, are made from cholesterol 

Dr. Deborah Gordon and I revisit hormone therapy in response to your strong interest in the topic. The conversation moves from lived experience to clinical nuance—how different formulations behave, why dosing and monitoring matter, and how to think more precisely about risks and benefits, especially in menopause and in more complex settings like cancer history.

A candid, grounded discussion for anyone trying to make sense of hormones beyond the headlines.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

 Today though we dive into what has surprised us both:  the hazards of ??too much?? exercise. 

 When might exercise have a dark side, when should we think twice about our exercise habits? And how might we tweak our exercise routine to get the most benefit from the time we do spend being active. Join us as we pore over some of the details.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

The episode explores emerging evidence that simply having ADD/ADHD raises lifetime Alzheimer’s risk—yet appropriately treating it in adults, often with low-dose stimulants, seems to push that risk back down. How can the same class of drugs be both feared as “brain-burning” and yet potentially brain-saving—and what does that mean for people already in midlife?

Treating prostate cancer successfully with--testosterone? 

Listeners are introduced to a first-in-oncology “directed evolution” case in metastatic prostate cancer, led by Dr. Lemanne’s team, where high-dose testosterone was deliberately used to expand treatment-sensitive cells—and only then was hormone blockade re-introduced. But did this radical, counterintuitive maneuver actually work?

Emotional trauma in youth as a hidden Alzheimer’s driver? Dr. Gordon discusses links between youth emotional trauma to higher rates of Alzheimer’s decades later, even in people who appear to have “moved on.” Is this just correlation, or should early emotional trauma be considered a subtle form of brain injury that can and should be addressed?

Do you go to bed later on weekends, by just 1-2 hours, but make up for it by rising later?  If so, you'll want to know that you may be increasing your risk of breast or prostate cancer.  This episode explores that research.

Have you heard of the new Alzheimer’s blood tests, that improve as the patient improves, allowing better direction of treatment? 

Dr. Gordon walks us through the ATN panel (amyloid-beta, p-tau, neurofilament light), now accessible through routine laboratory tests, along with galectin-3 as a tau-clustering, inflammation-linked marker, and a new infusion drug (TB006) targeting that pathway. But can these numbers really be moved in the right direction with targeted lifestyle and medical interventions—and what happens when they are?

Enjoy this unusual episode! 

And write to us. We read every email.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

I'll admit this sounds like astrology. Or science fiction. 

It isn't.

Statistics show that the number of sunspots during the year you were born  shortens your lifespan, on average, by more than a decade. 

And sunlight affects us in other strange ways. You may also be surprised to learn that living on the far western side of your time zone, or simply eating supper 8 PM compared to 6 PM, is associated with an increased risk of cancer.

This episode also covers

• why your cancer risk rises as you live farther from the equator (it's not all vitamin D)
• how changing your bedtime each night--by less than an hour!--quietly raises your risk of early death
• why your hospital room window determines how fast you heal

You’ll hear surprising data, real patient stories, and practical takeaways you can implement tonight. 

Want even more? Find out how muscle size correlates with brain size. (Yep.)

And if you want your exercise to actually build muscle, Dr. Gordon tells you the best time of day to get moving.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Learn why short bursts of stress are a tonic, while chronic stress damages your brain and accelerates tumor growth. Especially if you're female.  

Find out why you're wrong about your own stress levels, and what you must do to find the hidden stress before you can fix it.

Discover which meditation practices actually calm your nervous system. Many of the most popular simply won't work for you. The doctors themselves get completely opposite results from the same techniques. 

Dump the widespread belief that any exercise is fights cancer. For example, the walking routines doctors recommend do almost nothing. Find out what the data show actually works to stunt cancer growth.

Plus, learn about the overlooked hormone (most PCPs never think about this) your stressed body steals from your brain, how this theft leaves your brain vulnerable to stress-induced damage, and how Dr Gordon fixes this in her patients with an over-the-counter supplement.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Swimmers and Cyclists, Brace Yourselves…
Low-impact exercise sounds great—until you hear why some athletes have weaker bones than couch potatoes.

The CDC’s Bizarre Osteoporosis ‘Cure’
Would you believe field hockey for strenghthening bones was once an official recommendation? Find out what that says about mainstream osteoporosis advice—and why it’s time to rethink it.

80-Year-Old Diane’s Secret to Jumping Higher Than You
An explosive workout transformed this grandmother’s strength—but there’s a catch: your brain will actively try to stop you from doing the same. How to tame your brain so it is on the same team as your bones and joints.

Your Brain Is Sabotaging Your Joints
Meet neuromediation, the hidden reason arthritis pain worsens—and the surprising exercises that rewire your brain to fight back.

Why Bone Density Scans Miss 80% of Fracture Risks
Your DEXA scan isn’t telling you the whole story. So what actually predicts a broken hip? The answer will change how you think about osteoporosis.

Creatine + Coffee = Flushing $$$ Down the Drain?
A world-renowned researcher shares a timing hack that makes supplements actually work. Here is a link to a dosing guideline mentioned in the episode. (You must be sure to check with your own doctor before starting any supplement!)

Swimmers and Cyclists, Brace Yourselves…
Low-impact exercise sounds great—until you hear why some athletes have weaker bones than couch potatoes.

This isn’t about aging gracefully—it’s about aging powerfully. Ready to rewrite the rules? Listen now.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Doctor Norwitz also shares his insights about the process of human change and just exactly what motivated him when he knew he needed to make changes for his own survival. Join us as we chat with the very doctor Norwitz, and be sure to check out the show notes for links to all of his social media appearances. These are not only brilliant but highly entertaining.

Here are links to just a few of his many ventures:
https://www.youtube.com/@nicknorwitzPhD

on X: https://x.com/nicknorwitz

Instagram: https://www.instagram.com/nicknorwitz/ 

and for links to all his publications and writings, visit his website @ 

https://www.nicknorwitz.com/

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

• Breast cancers spread at night, and why this means trouble if your largest meal is supper.
• In colorectal cancer patients, morning chemo benefits men, while afternoon chemo benefits women.
• Light exposure at night disrupts sleep in everyone, immediately increasing the risk of diabetes and cancer.
• Vigorous exercise instantly creates cancer-killing effects in the blood that last for two hours.
• A single night of poor sleep causes high blood glucose and junk food cravings the very next day.

References:

Metastatic spread of breast cancer accelerates during sleep. Nature 2022
https://pubmed.ncbi.nlm.nih.gov/35732738/

Reducing nighttime light exposure in the urban environment to benefit human health and society. Science. https://www.science.org/doi/epdf/10.1126/science.adg5277. Accessed September 25, 2024.

Effects of anthropogenic light on health. Science. https://www.science.org/doi/10.1126/science.adg3173. Accessed September 25, 2024.

Light disrupts sleep and metabolic health. NPR. https://www.npr.org/sections/health-shots/2022/04/01/1089997121/light-disrupts-sleep. Accessed September 25, 2024.

Disruption of sleep due to light exposure increases insulin resistance and heart rate. PNAS. https://www.pnas.org/doi/10.1073/pnas.2113290119. Accessed September 25, 2024.

West KE, Jablonski MR, Warfield B, et al. Blue light exposure suppresses melatonin and impacts circadian rhythms. J Biol Rhythms. 2015;30(6):537-546. https://pubmed.ncbi.nlm.nih.gov/30311830/. Accessed September 25, 2024.

Effects of artificial light at night on human health: a review of epidemiological studies. Int J Occup Med Environ Health. 2015;28(4):563-571. https://pubmed.ncbi.nlm.nih.gov/26375320/. Accessed September 25, 2024.

Chronic sleep restriction minimizes circadian disruption, preserving glucose tolerance. Diabetes Care. 2021;44(3):839-844. https://pubmed.ncbi.nlm.nih.gov/34744800/. Accessed September 25, 2024.

Circadian rhythms and cognitive function. Nat Rev Neurosci. 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743892/. Accessed September 25, 2024.

Hall J, Rosbash M, Young M. Nobel Prize in Physiology or Medicine 2017: research on circadian rhythms. Nobel Prize Press Release. https://www.nobelprize.org/prizes/medicine/2017/press-release/. Accessed September 25, 2024.

Light at night and increased stroke risk. Stroke. 2024. https://www.sciencedaily.com/releases/2024/03/240325172425.htm. Accessed September 25, 2024.

Association of light exposure during sleep and obesity in women. JAMA Intern Med. 2020;180(9):1172-1173. https://pubmed.ncbi.nlm.nih.gov/31180469/. Accessed September 25, 2024.

Ballesta A, Innominato PF, Dallmann R, et al. Chemothe

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

But the news is not all good--fecal transplants can also transfer obesity. We discuss how a patient who received an FMT from an obese donor gained weight, highlighting just how powerful and influential the microbiome is in regulating metabolism.

We discuss the remarkable ability of bariatric surgery ("stomach stapling," for obesity) to resolve type 2 diabetes in just a few days—long before any weight loss occurs, and the mind-boggling reason for this counterintuitive occurrence.

Lifting weights is better than psychotherapy? Believe it or not, resistance training is found to be 1.5 times more effective than medication or talk therapy for treating anxiety and depression. 

And also in the realm of psychiatry, we explore Morgellon's disease. Patients with this condition report colorful fibers growing from their skin. Long considered a psychiatric disorder with delusions, (a misdiagnosis that has confined patients wrongly to inpatient mental health institutions) recent research finds a link between the colorful fibers of Morgellon's and Lyme disease.

Join us as we explore unexpected solutions to the toughest health challenges.

References:

Morgellons disease psychiatric condition or spirochetal infection? National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647328/. Accessed September 24, 2024.

Morgellons disease linked to infection. Dove Press. https://www.dovepress.com/getfile.php?fileID=69133. Accessed September 24, 2024.

Links between Morgellons and Lyme disease. LymeDisease.org. https://www.lymedisease.org/links-morgellons-lyme-disease/. Accessed September 24, 2024.

NAC alleviates OCD behaviors: Skin-picking, trichotillomania, etc. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909310/. Accessed September 24, 2024.

The nucleus accumbens and its role in reward, addiction, and pain. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975138/. Accessed September 24, 2024.

Defecation increases athletic performance by increasing brain oxygenation. PubMed. https://pubmed.ncbi.nlm.nih.gov/37102434/. Accessed September 24, 2024.

Bariatric surgery decreases breast cancer risk. MDedge. https://ma1.mdedge.com/obgyn/article/269409/breast-cancer/bariatric-surgery-may-reduce-breast-cancer-risk-some?ecd=WNL_EVE_240603_mdedge. Accessed September 24, 2024.

Infectious agents and cancer. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964319/. Accessed September 24, 2024.

Infectious agents including SARS-CoV-2 linked to cancer. Frontiers. https://www.frontiersin.org/articles/10.3389/fcell.2022.876180/full. Accessed September 24, 2024.

Exercise is 1.5 times more effective than drugs for depression and anxiety. Medical News Today. 

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

1. Alcohol and Cancer Risk
   “In women, breast cancer includes over half of all tumors caused by alcohol.”
   Source: Starek M, Rogalska A. Alcohol consumption and cancer risk. Pharmacological Reports. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889462/pdf/43440_2022_Article_426.pdf​:contentReference[oaicite:0]{index=0}
2. Genetic Differences in Alcohol Metabolism
   “Individuals differ in their ability to metabolize ethanol through genetic differences in ADH [alcohol dehydrogenase].”
   Source: Starek M, Rogalska A. Pharmacological Reports. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889462/pdf/43440_2022_Article_426.pdf​:contentReference[oaicite:1]{index=1}
3. Alcohol and Cancer Types
   Cancers linked to alcohol include breast, colorectal, liver, pancreatic, and head/neck cancers.
   Source: Molina Y, et al. Alcohol and cancer risk: A global review. Epidemiol Health. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867516/pdf/epih-45-e2023092.pdf​:contentReference[oaicite:2]{index=2}
4. Alcohol and Cognitive Decline
   Moderate drinking increases cognitive decline by 10-15% in men consuming 3+ drinks per day.
   Source: Sabia S, et al. Alcohol consumption and cognitive decline in early old age. Neurology. 2014;82(4):332-339. doi:10.1212/WNL.0000000000000063​​
5. Alcohol and Sleep
   Alcohol reduces REM sleep, disrupts heart rate variability, and fragments sleep, worsening cognitive outcomes.
   Source: Walker M. Why We Sleep: Unlocking the Power of Sleep and Dreams. Available from: https://www.webmd.com/healthy-aging/what-to-know-about-alcohol-as-you-get-older​:contentReference[oaicite:5]{index=5}
6. Coffee and Cognitive Health
   Higher coffee consumption is l

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

• common blood pressure and diabetes medications that derail your fitness program
• sarcopenia of aging starts not in the muscles, but in the brain
• fitness to treat cognitive decline and neurologic disorders, Parkinson, MS, stroke
• yoga, and the surprisingly high risk of injury 
• why stretching is harmful, and a better way to maintain range-of-motion 
•  heart disease vs lung disease: the very different exercise rehab programs required
• rheumatoid arthritis, why your exercise program is all wrong, and how to fix it
• when to build muscle strength, and when to build muscle mass
• why exercise is superior to calorie restriction for managing weight
• why COPD patients must limit aerobic exercise and should build muscle mass instead
• Different types of exercise as medicine for aging, cancer, heart disease, high blood pressure, autoimmune conditions, dementia, osteoporosis, diabetes, lung disease/COPD and much more...

Our guest is an elite rower turned Exercise Medicine specialist, author, inventor, and specialist in fitness over 50. Meet Andy Baxter. Besides designing exercise equipment to curtail injury in elite athletes, he runs two gyms locally that cater to those over 50, and works privately with anyone in need of his specialty, "Medical Exercise."

Find Andy Baxter at Baxter Fitness Solutions.
Read Andy Baxter's book "The Exercise Prescription."

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

In this thought-provoking episode, we explore the discovery of the link between diet, glucose metabolism, and cancer growth. Join us as we sit down with Sam Apple, the author of the compelling book, "Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection."

Our guest, Sam Apple, tells the hidden story of Otto Warburg, a Nobel laureate who in spite of his Jewish heritage, not only survived Hitler's Germany, but uncovered the link between  sugar and cancer. 

Sugar, Cancer, and the Rise of Cancer Rates

We kick off our conversation with a startling revelation: Germany's financial ruin and desperate quest to compete with sugar-cane-producing European powers drove the mass cultivation of sugar beets for table sugar production. Sam Apple points out how this historic shift in diet and the rampant consumption of sugar may have played a pivotal role in the alarming rise of cancer rates over the past two centuries. Prepare to be astounded by the unexpected connection between sugar, cancer, and world history.

Hitler's Sugar Addiction and Ironic Phobia

As we dig deeper into the narrative, we explore the eccentricities of history's most infamous dictator, Adolf Hitler. Discover how Hitler's insatiable sugar addiction led to the deterioration of his health, even causing his teeth to rot. The irony of Hitler's profound fear of cancer while he indulged in a sugar-laden lifestyle serves as a stark reminder of the hidden dangers lurking in our diets.

Warburg's Survival and Post-War Ostracism

Otto Warburg survived Nazi Germany, only to find himself and his work shunned by the post-war cancer research establishment in the United States. This unfortunate political reality led to a nearly 100-year delay in connecting the dots between diet and cancer. 

Sam Apple's Personal Transformation

Our guest, Sam Apple, shares the profound impact Otto Warburg's work had on his own lifestyle choices. Discover the dietary changes that Sam has embraced as he continues to uncover the secrets of cancer prevention, inspired by the remarkable legacy of Otto Warburg.

Prepare to be captivated, enlightened, and inspired by this eye-opening conversation that bridges the gap between history, science, and personal wellness. Whether you're a cancer patient seeking new insights or someone passionate about preventive healthcare, this podcast promises to provide you with valuable knowledge that can transform your understanding of cancer prevention.

More on Sam Apple
Link to Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection 

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

• Exactly when to fast for best cancer outcome
• Combining fasting and chemotherapy improves survival--animal studies
• Types of fasts, including water fasts and dry fasts
• Research on dry fasting and kidney function (prepare to be surprised)
• Eating dinner late increases cancer risk
• Daily intermittent fasting, minimum effective length
• Extended fasts

Meth EMS, van Egmond LT, Moulin TC, Cedernaes J, Rosqvist F, Benedict C. Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men. Front Nutr. 2022 May 10;9:889926. doi: 10.3389/fnut.2022.889926. PMID: 35619965; PMCID: PMC9127957.

Links and references of interest:

Study evaluating the effect of late dinner on breast and prostate cancer risk 

Chemotherapy and timing of fasting, University of Southern California study

Chemotherapy patients who fast report fewer side effects. Longo group, 2009

UCSF fasting page has been taken down. Here is one from City of Hope Cancer Center, in southern California/ greater Los Angeles area

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. Longo group, 2012 PMID: 22323820

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

• Why the health of your smallest blood vessels dictates your overall health and longevity picture, and how to measure this. 
  
  
• How your "natural killer cells" are related to cancer, and the special blood test that can measure the fitness of these cells. 
  
  
• Why medicinal mushrooms enhance health.

And much more. 

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

• Evaluating cognitive impairment: subjective vs measurable? 
• Distinguishing mild cognitive impairment from early Alzheimer's dementia
• Which interventions actually moved the needle? 

 Along the way, we dive into details on mechanisms.

Time stamps with links to references and resources:

11:51     Chewing enhances brain health 

13:59    observational study of 10 patients with dementia undergoing lifestyle intervention “Reversal of cognitive decline:  A novel therapeutic program.” 

15:11     CNS-Vital Signs test  

22:29    Hormesis

23:24     Intellxx DNA testing  https://www.intellxxdna.com/ 

29:46     Cyrex testing

36:00   Study: Do US patients on colon cancer chemotherapy have more side effects due to increased amounts of folic acid in enriched foods? 

39:50     Link to Dr Gordon’s mold you tube talk  

41:15     Link to Dr. Gordon's recent research “Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project” in Journal of Alzheimer’s Disease, 2022; 88(4): 1411-1421.

46:52    Finland and Iceland high rates of AD    
and
“Why Does Finland have the highest dementia mortality rate?"

47:10     Online resources for people who are still functioning very well, but believe themselves at risk for dementia

·        BrainHQ 

·        Brainjo

·        Food for the Brain

Resources for a more intensive therapeutic approach

·      Apollo Health 

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

 In this episode, Dr. Gordon discusses female hormones. She gives us a glimpse into their function and what happens to aging women as they lose those hormones in menopause. She also talks about the skillful use of hormone replacement to extend life and enhance its quality. For those women who don’t or can’t take the typical form of hormone replacement therapy,  she describes workarounds for benefit of both brain and bone health.

Links to references and more reading on some of the topics mentioned:

1.  Increased Alzheimer’s Risk During the Menopause Transition

2.  Mercury and Lead toxicity in menopause-induced osteopenia

3.  Estrogen receptors are complicated, we'll address in a future episode, but here's a brief, layman's terms summary.

4.  Comprehensive genetics testing provider, IntellxxDNA

5.  Hormone replacement therapy  prescribed for women aged 57-82 was associated with a significant improvement in tests of cognitive function at 24 months.   

6.  Testing estrogen metabolites in the urine.   

7.  Foods included in a conventional Polish diet—cabbage and sauerkraut—are associated with a reduced risk of breast cancer in Polish migrant workers.

8.   Genistein can confer protection against bone loss  and is emerging as a therapeutic option against the pathogenesis of memory impairment.  

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

The four diagnoses include chronic lymphocytic leukemia (CLL), advanced ovarian cancer, metastatic prostate cancer, and metastatic melanoma.

Several surprising ideas that come up in this episode include why having chemotherapy before surgery is often better than rushing to surgery, and how the principles of evolution (as in Darwin) are pointing to lighter, more infrequent cancer treatments as a way to prolong both healthspan and lifespan. 

Links, Episode 1:

 1. MIT research demonstrating the detrimental effect of surgery on cancer metastasis.

2. How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence. 

3. N of 1,  by Glenn Sabin and Dawn Lemanne, MD, MPH.  The popular book about Mr. Sabin's successful search for a cure for his "incurable" chronic lymphocytic leukemia. 

4. Case report of durable CLL remission without standard systemic therapy: Lemanne D, Block KI, Kressel BR, Sukhatme VP, White JD. A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea. 

5. Research demonstrating that maximal PSA suppression may be detrimental in advanced prostate cancer.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains